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Application of a New Gene-Cell Construct Based on the Olfactory Mucosa Escheating Cells Transduced with an Adenoviral Vector Encoding Mature BDNF in the Therapy of Spinal Cord Cysts.
Karsuntseva, E K; Fursa, G A; Sosnovtseva, A O; Voronova, A D; Chadin, A V; Semkina, A S; Stepanova, O V; Chekhonin, V P.
Afiliación
  • Karsuntseva EK; V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Fursa GA; M. V. Lomonosov Moscow State University, Moscow, Russia.
  • Sosnovtseva AO; V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Voronova AD; V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia. nastyanastyav@mail.ru.
  • Chadin AV; V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Semkina AS; V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Stepanova OV; Pirogov Russian National Research Medical University, Moscow, Russia.
  • Chekhonin VP; V. P. Serbsky National Medical Research Centre of Psychiatry and Narcology, Ministry of Health of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med ; 172(5): 617-621, 2022 Mar.
Article en En | MEDLINE | ID: mdl-35352253
A gene-cell construct based on rat olfactory mucosa ensheathing cells transduced with an adenoviral vector encoding a mature form of brain neurotrophic factor (mBDNF) was transplanted into post-traumatic cysts of rat spinal cord. Transplantation of the gene-cell construct improved motor activity of the hind limbs and reduced the size of cysts in some animals. However, comparison of the effects of transduced and non-transduced ensheathing cells revealed no significant differences. In parallel in vitro experiments, a decrease in the proliferation of transduced cells compared to non-transduced cells was observed. It is likely that mBDNF reduces proliferation of transduced cells, which can affect their efficiency. The therapeutic efficacy of the new gene-cell construct is most likely provided by the cellular component.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Quistes Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2022 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Traumatismos de la Médula Espinal / Quistes Límite: Animals Idioma: En Revista: Bull Exp Biol Med Año: 2022 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Estados Unidos