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Timing of Pubertal Development in Boys and Girls With Congenital Heart Defects: A Nationwide Cohort Study.
Udholm, Louise F; Gaml-Sørensen, Anne; Arendt, Linn H; Brix, Nis; Lunddorf, Lea L H; Ernst, Andreas; Knudsen, Ulla B; Hjortdal, Vibeke E; Ramlau-Hansen, Cecilia H.
Afiliación
  • Udholm LF; Department of Cardiothoracic Surgery Copenhagen University Hospital Copenhagen Denmark.
  • Gaml-Sørensen A; Department of Clinical Medicine Copenhagen University Copenhagen Denmark.
  • Arendt LH; Department of Public Health Research Unit for Epidemiology Aarhus University Aarhus Denmark.
  • Brix N; Department of Public Health Research Unit for Epidemiology Aarhus University Aarhus Denmark.
  • Lunddorf LLH; Department of Public Health Research Unit for Epidemiology Aarhus University Aarhus Denmark.
  • Ernst A; Department of Obstetrics and Gynaecology Horsens Regional Hospital Horsens Denmark.
  • Knudsen UB; Department of Public Health Research Unit for Epidemiology Aarhus University Aarhus Denmark.
  • Hjortdal VE; Department of Clinical Genetics Aarhus University Hospital Aarhus Denmark.
  • Ramlau-Hansen CH; Department of Public Health Research Unit for Epidemiology Aarhus University Aarhus Denmark.
J Am Heart Assoc ; 11(7): e023135, 2022 04 05.
Article en En | MEDLINE | ID: mdl-35347999
Background Children with congenital heart defects (CHD) have an increased risk of developmental delay. It remains sparsely investigated if these patients also have a delayed pubertal development. In this nationwide cohort study, we evaluated if CHD was associated with timing of puberty using longitudinally collected data on pubertal milestones. Methods and Results We used data from the Danish nationwide Puberty Cohort. Information on CHD was obtained from the Danish National Patient Register. Information on pubertal development was obtained from 15 780 children through questionnaires answered half-yearly from 11 years until 18 years or full maturity. Using a multivariable regression model for censored time-to-event data, mean difference in age at attaining each pubertal milestone was estimated, including a combined pubertal marker. Compared with children without CHD, analyses were performed for both CHD overall and subdivided into simple and complex CHD. In a subanalysis, analyses were repeated in children born at term. In total, 137 children (62 boys and 75 girls) had a CHD diagnosis. Overall, no difference in age at pubertal timing was observed for children with CHD compared with unaffected children. The average differences were small for both boys (1.6 [95% CI, -2.6 to 5.7] months) and girls (1.0 [95% CI, -2.5 to 4.4] months). The same differences were observed when subdividing into simple or complex CHD and when restricting to children born at term. Conclusions We found no association between CHD and pubertal timing. For the group of children with complex CHD, we were unable to exclude a later pubertal timing.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pubertad / Cardiopatías Congénitas Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male / Pregnancy Idioma: En Revista: J Am Heart Assoc Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pubertad / Cardiopatías Congénitas Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Child / Female / Humans / Male / Pregnancy Idioma: En Revista: J Am Heart Assoc Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido