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A TMPRSS2 inhibitor acts as a pan-SARS-CoV-2 prophylactic and therapeutic.
Shapira, Tirosh; Monreal, I Abrrey; Dion, Sébastien P; Buchholz, David W; Imbiakha, Brian; Olmstead, Andrea D; Jager, Mason; Désilets, Antoine; Gao, Guang; Martins, Mathias; Vandal, Thierry; Thompson, Connor A H; Chin, Aaleigha; Rees, William D; Steiner, Theodore; Nabi, Ivan Robert; Marsault, Eric; Sahler, Julie; Diel, Diego G; Van de Walle, Gerlinde R; August, Avery; Whittaker, Gary R; Boudreault, Pierre-Luc; Leduc, Richard; Aguilar, Hector C; Jean, François.
Afiliación
  • Shapira T; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
  • Monreal IA; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
  • Dion SP; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.
  • Buchholz DW; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
  • Imbiakha B; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
  • Olmstead AD; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
  • Jager M; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
  • Désilets A; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.
  • Gao G; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
  • Martins M; Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
  • Vandal T; Department of Population Medicine and Diagnostic Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
  • Thompson CAH; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.
  • Chin A; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
  • Rees WD; Department of Microbiology and Immunology, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
  • Steiner T; Department of Medicine, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
  • Nabi IR; Department of Medicine, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, British Columbia, Canada.
  • Marsault E; Department of Cellular and Physiological Sciences, Life Sciences Institute, University of British Columbia, Vancouver, British Columbia, Canada.
  • Sahler J; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.
  • Diel DG; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
  • Van de Walle GR; Department of Population Medicine and Diagnostic Sciences, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
  • August A; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
  • Whittaker GR; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
  • Boudreault PL; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA.
  • Leduc R; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.
  • Aguilar HC; Department of Pharmacology-Physiology, Faculty of Medicine and Health Sciences, Institut de Pharmacologie de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada. richard.leduc@usherbrooke.ca.
  • Jean F; Department of Microbiology and Immunology, Cornell University College of Veterinary Medicine, Ithaca, NY, USA. ha363@cornell.edu.
Nature ; 605(7909): 340-348, 2022 05.
Article en En | MEDLINE | ID: mdl-35344983
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Serina Proteinasa / SARS-CoV-2 / COVID-19 Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nature Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Inhibidores de Serina Proteinasa / SARS-CoV-2 / COVID-19 Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Nature Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido