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Trace amine-associated receptor 1 and drug abuse.
Wu, Ruyan; Liu, Jianfeng; Li, Jun-Xu.
Afiliación
  • Wu R; Medical College of Yangzhou University, Yangzhou, China; Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, United States.
  • Liu J; Department of Psychological and Brain Sciences, College of Liberal Arts, Texas A&M University, College Station, TX, United States.
  • Li JX; Department of Pharmacology and Toxicology, University at Buffalo, Buffalo, NY, United States. Electronic address: junxuli@buffalo.edu.
Adv Pharmacol ; 93: 373-401, 2022.
Article en En | MEDLINE | ID: mdl-35341572
Trace amine-associated receptor 1 (TAAR1) is the best characterized receptor selectively activated by trace amines. It is broadly expressed in the monoaminergic system in the brain including ventral tegmental area (VTA), nucleus accumbens (NAc), dorsal raphe (DR) and substantial nigra (SN). Extensive studies have suggested that TAAR1 plays an important role in the modulation of monoaminergic system, especially dopamine (DA) transmission which may underlie the mechanisms by which TAAR1 interventions affect drug abuse-like behaviors. TAAR1 activation inhibits the rewarding and reinforcing effects of drugs from different classes including psychostimulants, opioid and alcohol as well as drug-induced increase in DA accumulation. The mechanisms of TAAR1's function in mediating drug abuse-like behaviors are not clear. However, it is hypothesized that TAAR1 interaction with DA transporter (DAT) and dopamine D2 receptor (D2) and the subsequent modulation of cellular cascades may contribute to the effects of TAAR1 in regulating drug abuse. Further studies are needed to investigate the role of TAAR1 in other drugs of abuse-related behaviors and its safety and efficacy for prolonged medications. Together, TAAR1 inhibits drug-induced DA transmission and drug abuse-related behaviors. Therefore, TAAR1 may be a promising therapeutic target for the treatment of drug addiction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Relacionados con Sustancias / Estimulantes del Sistema Nervioso Central Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Adv Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Relacionados con Sustancias / Estimulantes del Sistema Nervioso Central Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: Adv Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos