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Iatrogenic Iron Promotes Neurodegeneration and Activates Self-Protection of Neural Cells against Exogenous Iron Attacks.
Xia, Maosheng; Liang, Shanshan; Li, Shuai; Ji, Ming; Chen, Beina; Zhang, Manman; Dong, Chengyi; Chen, Binjie; Gong, Wenliang; Wen, Gehua; Zhan, Xiaoni; Zhang, Dianjun; Li, Xinyu; Zhou, Yuefei; Guan, Dawei; Verkhratsky, Alexei; Li, Baoman.
Afiliación
  • Xia M; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
  • Liang S; Department of Orthopaedics, The First Hospital, China Medical University, Shenyang, People's Republic of China.
  • Li S; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
  • Ji M; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
  • Chen B; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
  • Zhang M; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
  • Dong C; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
  • Chen B; Department of Orthopaedics, The First Hospital, China Medical University, Shenyang, People's Republic of China.
  • Gong W; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
  • Wen G; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
  • Zhan X; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
  • Zhang D; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
  • Li X; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
  • Zhou Y; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
  • Guan D; Department of Orthopaedics, The First Hospital, China Medical University, Shenyang, People's Republic of China.
  • Verkhratsky A; Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang, China.
  • Li B; Practical Teaching Centre, School of Forensic Medicine, China Medical University, Shenyang, People's Republic of China.
Function (Oxf) ; 2(2): zqab003, 2021.
Article en En | MEDLINE | ID: mdl-35330817
Metal implants are used worldwide, with millions of nails, plates, and fixtures grafted during orthopedic surgeries. Iron is the most common element of these metal implants. As time passes, implants can be corroded and iron can be released. Ionized iron permeates the surrounding tissues and enters circulation; importantly, iron ions pass through the blood-brain barrier. Can iron from implants represent a risk factor for neurological diseases? This remains an unanswered question. In this study, we discovered that patients with metal implants delivered through orthopedic surgeries have higher incidence of Parkinson's disease or ischemic stroke compared to patients who underwent similar surgeries but did not have implants. Concentration of serum iron and ferritin was increased in subjects with metal implants. In experiments in vivo, we found that injection of iron dextran selectively decreased the presence of divalent metal transporter 1 (DMT1) in neurons through increasing the expression of Ndfip1, which degrades DMT1 and does not exist in glial cells. At the same time, excess of iron increased expression of DMT1 in astrocytes and microglial cells and triggered reactive astrogliosis and microgliosis. Facing the attack of excess iron, glial cells act as neuroprotectors to accumulate more extracellular iron by upregulating DMT1, whereas neurons limit iron uptake through increasing DMT1 degradation. Cerebral accumulation of iron in animals is associated with impaired cognition, locomotion, and mood. Excess iron from surgical implants thus can affect neural cells and may be regarded as a risk factor for neurodegeneration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hierro / Neuronas Límite: Animals Idioma: En Revista: Function (Oxf) Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hierro / Neuronas Límite: Animals Idioma: En Revista: Function (Oxf) Año: 2021 Tipo del documento: Article Pais de publicación: Reino Unido