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GSTO1, GSTO2 and ACE2 Polymorphisms Modify Susceptibility to Developing COVID-19.
Djukic, Tatjana; Stevanovic, Goran; Coric, Vesna; Bukumiric, Zoran; Pljesa-Ercegovac, Marija; Matic, Marija; Jerotic, Djurdja; Todorovic, Nevena; Asanin, Milika; Ercegovac, Marko; Ranin, Jovan; Milosevic, Ivana; Savic-Radojevic, Ana; Simic, Tatjana.
Afiliación
  • Djukic T; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  • Stevanovic G; Institute of Medical and Clinical Biochemistry, 11000 Belgrade, Serbia.
  • Coric V; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  • Bukumiric Z; Clinic of Infectious and Tropical Diseases, Clinical Centre of Serbia, 11000 Belgrade, Serbia.
  • Pljesa-Ercegovac M; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  • Matic M; Institute of Medical and Clinical Biochemistry, 11000 Belgrade, Serbia.
  • Jerotic D; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  • Todorovic N; Institute of Medical Statistics and Informatics, 11000 Belgrade, Serbia.
  • Asanin M; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  • Ercegovac M; Institute of Medical and Clinical Biochemistry, 11000 Belgrade, Serbia.
  • Ranin J; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  • Milosevic I; Institute of Medical and Clinical Biochemistry, 11000 Belgrade, Serbia.
  • Savic-Radojevic A; Faculty of Medicine, University of Belgrade, 11000 Belgrade, Serbia.
  • Simic T; Institute of Medical and Clinical Biochemistry, 11000 Belgrade, Serbia.
J Pers Med ; 12(3)2022 Mar 14.
Article en En | MEDLINE | ID: mdl-35330457
Based on the close relationship between dysregulation of redox homeostasis and immune response in SARS-CoV-2 infection, we proposed a possible modifying role of ACE2 and glutathione transferase omega (GSTO) polymorphisms in the individual propensity towards the development of clinical manifestations in COVID-19. The distribution of polymorphisms in ACE2 (rs4646116), GSTO1 (rs4925) and GSTO2 (rs156697) were assessed in 255 COVID-19 patients and 236 matched healthy individuals, emphasizing their individual and haplotype effects on disease development and severity. Polymorphisms were determined by the appropriate qPCR method. The data obtained showed that individuals carrying variant GSTO1*AA and variant GSTO2*GG genotypes exhibit higher odds of COVID-19 development, contrary to ones carrying referent alleles (p = 0.044, p = 0.002, respectively). These findings are confirmed by haplotype analysis. Carriers of H2 haplotype, comprising GSTO1*A and GSTO2*G variant alleles were at 2-fold increased risk of COVID-19 development (p = 0.002). Although ACE2 (rs4646116) polymorphism did not exhibit a statistically significant effect on COVID-19 risk (p = 0.100), the risk of COVID-19 development gradually increased with the presence of each additional risk-associated genotype. Further studies are needed to clarify the specific roles of glutathione transferases omega in innate immune response and vitamin C homeostasis once the SARS-CoV-2 infection is initiated in the host cell.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Pers Med Año: 2022 Tipo del documento: Article Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Pers Med Año: 2022 Tipo del documento: Article Pais de publicación: Suiza