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The Fight against Cancer by Microgravity: The Multicellular Spheroid as a Metastasis Model.
Grimm, Daniela; Schulz, Herbert; Krüger, Marcus; Cortés-Sánchez, José Luis; Egli, Marcel; Kraus, Armin; Sahana, Jayashree; Corydon, Thomas J; Hemmersbach, Ruth; Wise, Petra M; Infanger, Manfred; Wehland, Markus.
Afiliación
  • Grimm D; Department of Microgravity and Translational Regenerative Medicine, Medical Faculty, University Hospital Magdeburg, Otto von Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany.
  • Schulz H; Clinic for Plastic, Aesthetic and Hand Surgery, Medical Faculty, University Hospital Magdeburg, Otto von Guericke University, Leipziger Straße 44, 39120 Magdeburg, Germany.
  • Krüger M; Research Group 'Magdeburger Arbeitsgemeinschaft für Forschung unter Raumfahrt- und Schwerelosigkeitsbedingungen' (MARS), Otto von Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany.
  • Cortés-Sánchez JL; Department of Biomedicine, The Faculty of Health, Aarhus University, Ole Worms Allé 4, 8000 Aarhus, Denmark.
  • Egli M; Department of Microgravity and Translational Regenerative Medicine, Medical Faculty, University Hospital Magdeburg, Otto von Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany.
  • Kraus A; Clinic for Plastic, Aesthetic and Hand Surgery, Medical Faculty, University Hospital Magdeburg, Otto von Guericke University, Leipziger Straße 44, 39120 Magdeburg, Germany.
  • Sahana J; Research Group 'Magdeburger Arbeitsgemeinschaft für Forschung unter Raumfahrt- und Schwerelosigkeitsbedingungen' (MARS), Otto von Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany.
  • Corydon TJ; Department of Microgravity and Translational Regenerative Medicine, Medical Faculty, University Hospital Magdeburg, Otto von Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany.
  • Hemmersbach R; Research Group 'Magdeburger Arbeitsgemeinschaft für Forschung unter Raumfahrt- und Schwerelosigkeitsbedingungen' (MARS), Otto von Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany.
  • Wise PM; Department of Microgravity and Translational Regenerative Medicine, Medical Faculty, University Hospital Magdeburg, Otto von Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany.
  • Infanger M; Space Biology Group, Institute of Medical Engineering, Lucerne University of Applied Sciences and Arts, 6002 Hergiswil, Switzerland.
  • Wehland M; Department of Microgravity and Translational Regenerative Medicine, Medical Faculty, University Hospital Magdeburg, Otto von Guericke University, Universitätsplatz 2, 39106 Magdeburg, Germany.
Int J Mol Sci ; 23(6)2022 Mar 12.
Article en En | MEDLINE | ID: mdl-35328492
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality. Therefore, groundbreaking research and innovations are necessary. Research in space under microgravity (µg) conditions is a novel approach with the potential to fight cancer and develop future cancer therapies. Space travel is accompanied by adverse effects on our health, and there is a need to counteract these health problems. On the cellular level, studies have shown that real (r-) and simulated (s-) µg impact survival, apoptosis, proliferation, migration, and adhesion as well as the cytoskeleton, the extracellular matrix, focal adhesion, and growth factors in cancer cells. Moreover, the µg-environment induces in vitro 3D tumor models (multicellular spheroids and organoids) with a high potential for preclinical drug targeting, cancer drug development, and studying the processes of cancer progression and metastasis on a molecular level. This review focuses on the effects of r- and s-µg on different types of cells deriving from thyroid, breast, lung, skin, and prostate cancer, as well as tumors of the gastrointestinal tract. In addition, we summarize the current knowledge of the impact of µg on cancerous stem cells. The information demonstrates that µg has become an important new technology for increasing current knowledge of cancer biology.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ingravidez / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ingravidez / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans / Male Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza