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The Role of Hub and Spoke Regions in Theory of Mind in Early Alzheimer's Disease and Frontotemporal Dementia.
Orso, Beatrice; Lorenzini, Luigi; Arnaldi, Dario; Girtler, Nicola; Brugnolo, Andrea; Doglione, Elisa; Mattioli, Pietro; Biassoni, Erica; Massa, Federico; Peira, Enrico; Bauckneht, Matteo; Donegani, Maria I; Morbelli, Silvia; Nobili, Flavio; Pardini, Matteo.
Afiliación
  • Orso B; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Largo Daneo 3, 16132 Genoa, Italy.
  • Lorenzini L; Department of Radiology and Nuclear Medicine, Amsterdam UMC Location VuMC, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
  • Arnaldi D; Department of Radiology and Nuclear Medicine, Amsterdam UMC Location VuMC, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands.
  • Girtler N; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Largo Daneo 3, 16132 Genoa, Italy.
  • Brugnolo A; IRCCS Ospedale Policlinico S. Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy.
  • Doglione E; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Largo Daneo 3, 16132 Genoa, Italy.
  • Mattioli P; IRCCS Ospedale Policlinico S. Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy.
  • Biassoni E; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Largo Daneo 3, 16132 Genoa, Italy.
  • Massa F; IRCCS Ospedale Policlinico S. Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy.
  • Peira E; IRCCS Ospedale Policlinico S. Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy.
  • Bauckneht M; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Largo Daneo 3, 16132 Genoa, Italy.
  • Donegani MI; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Largo Daneo 3, 16132 Genoa, Italy.
  • Morbelli S; Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health (DINOGMI), University of Genoa, Largo Daneo 3, 16132 Genoa, Italy.
  • Nobili F; National Institute of Nuclear Physics (INFN), Genoa Section, Via Dodecaneso 33, 16146 Genoa, Italy.
  • Pardini M; IRCCS Ospedale Policlinico S. Martino, Largo Rosanna Benzi 10, 16132 Genoa, Italy.
Biomedicines ; 10(3)2022 Feb 24.
Article en En | MEDLINE | ID: mdl-35327346
Theory of mind (ToM, the ability to attribute mental states to others) deficit is a frequent finding in neurodegenerative conditions, mediated by a diffuse brain network confirmed by 18F-FDG-PET and MR imaging, involving frontal, temporal and parietal areas. However, the role of hubs and spokes network regions in ToM performance, and their respective damage, is still unclear. To study this mechanism, we combined ToM testing with brain 18F-FDG-PET imaging in 25 subjects with mild cognitive impairment due to Alzheimer's disease (MCI−AD), 24 subjects with the behavioral variant of frontotemporal dementia (bvFTD) and 40 controls. Regions included in the ToM network were divided into hubs and spokes based on their structural connectivity and distribution of hypometabolism. The hubs of the ToM network were identified in frontal regions in both bvFTD and MCI−AD patients. A mediation analysis revealed that the impact of spokes damage on ToM performance was mediated by the integrity of hubs (p < 0.001), while the impact of hubs damage on ToM performance was independent from the integrity of spokes (p < 0.001). Our findings support the theory that a key role is played by the hubs in ToM deficits, suggesting that hubs could represent a final common pathway leading from the damage of spoke regions to clinical deficits.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Biomedicines Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Biomedicines Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza