Benzo[a]pyrene metabolism by hepatic and extrahepatic tissues in streptozotocin-diabetic rats.
Drug Metab Dispos
; 7(1): 49-51, 1979.
Article
en En
| MEDLINE
| ID: mdl-35327
The metabolism of benzo[a]pyrene (BP) by microsomes from hepatic and extrahepatic tissues of female diabetic rats was investigated. Diabetes was produced by the administration of streptozotocin, 60 mg/kg iv, and BP metabolism was studied 7 or 10 days later. BP metabolism was increased in hepatic microsomes by 75% in diabetic animals. Cytochrome P-450 levels were similarly increased. BP mono-oxygenase activity was tripled in intestinal microsomes of diabetic rats, and returned to control values on insulin treatment. The BP mono-oxygenase activity in lung microsomes from diabetic rats decreased by 40%, and was increased to control levels after insulin treatment. No significant changes in BP metabolism were observed in the kidney and adrenal tissues of diabetic animals.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Benzopirenos
/
Diabetes Mellitus Experimental
/
Hígado
Límite:
Animals
Idioma:
En
Revista:
Drug Metab Dispos
Asunto de la revista:
FARMACOLOGIA
Año:
1979
Tipo del documento:
Article
Pais de publicación:
Estados Unidos