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A single oral dose of citalopram increases interoceptive insight in healthy volunteers.
Livermore, James J A; Holmes, Clare L; Moga, Gyorgy; Adamatzky, Kristian; Critchley, Hugo D; Garfinkel, Sarah N; Campbell-Meiklejohn, Daniel.
Afiliación
  • Livermore JJA; School of Psychology, University of Sussex, Pevensey Building, Falmer, Brighton, BN1 9QH, UK.
  • Holmes CL; Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, the Netherlands.
  • Moga G; School of Psychology, University of Sussex, Pevensey Building, Falmer, Brighton, BN1 9QH, UK.
  • Adamatzky K; School of Psychology, University of Sussex, Pevensey Building, Falmer, Brighton, BN1 9QH, UK.
  • Critchley HD; School of Psychology, University of Sussex, Pevensey Building, Falmer, Brighton, BN1 9QH, UK.
  • Garfinkel SN; Department of Neuroscience, Brighton and Sussex Medical School (BSMS), Brighton, UK.
  • Campbell-Meiklejohn D; Sackler Centre for Consciousness Science, University of Sussex, Brighton, UK.
Psychopharmacology (Berl) ; 239(7): 2289-2298, 2022 Jul.
Article en En | MEDLINE | ID: mdl-35325257
RATIONALE: Interoception is the signalling, perception, and interpretation of internal physiological states. Many mental disorders associated with changes of interoception, including depressive and anxiety disorders, are treated with selective serotonin reuptake inhibitors (SSRIs). However, the causative link between SSRIs and interoception is not yet clear. OBJECTIVES: To ascertain the causal effect of acute changes of serotonin levels on cardiac interoception. METHODS: Using a within-participant placebo-controlled design, forty-seven healthy human volunteers (31 female, 16 male) were tested on and off a 20 mg oral dose of the commonly prescribed SSRI, citalopram. Participants made judgements on the synchrony between their heartbeat and auditory tones and then expressed confidence in each judgement. We measured three types of interoceptive cognition. RESULTS: Citalopram increased cardiac interoceptive insight, measured as correspondence of self-reported confidence to the likelihood that interoceptive judgements were actually correct. This effect was driven by enhanced confidence for correct interoceptive judgements and was independent of measured cardiac and reported subjective effects of the drug. CONCLUSIONS: An acute change of serotonin levels can increase insight into the reliability of inferences made from cardiac interoceptive sensations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Concienciación / Citalopram Tipo de estudio: Clinical_trials Límite: Female / Humans / Male Idioma: En Revista: Psychopharmacology (Berl) Año: 2022 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Concienciación / Citalopram Tipo de estudio: Clinical_trials Límite: Female / Humans / Male Idioma: En Revista: Psychopharmacology (Berl) Año: 2022 Tipo del documento: Article Pais de publicación: Alemania