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Pharmacological evaluation of anti-arthritic potential of terpinen-4-ol using in vitro and in vivo assays.
Aslam, Sania; Younis, Waqas; Malik, Muhammad Nasir Hayat; Jahan, Shah; Uttra, Ambreen Malik; Munir, Muhammad Usman; Roman, Muhammad.
Afiliación
  • Aslam S; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.
  • Younis W; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan. wy216@njms.rutgers.edu.
  • Malik MNH; Department of Pharmacology, Physiology, and Neuroscience, New Jersey Medical School-Rutgers, Newark, NJ, 07103, USA. wy216@njms.rutgers.edu.
  • Jahan S; Department of Pharmacology, Faculty of Pharmacy, The University of Lahore, Lahore, Pakistan.
  • Alamgeer; Department of Immunology, University of Health Sciences, Lahore, Pakistan.
  • Uttra AM; University College of Pharmacy, University of the Punjab, Lahore, Pakistan.
  • Munir MU; College of Pharmacy, University of Sargodha, Sargodha, Pakistan.
  • Roman M; Department of Pharmaceutical Chemistry, College of Pharmacy, Jouf University, Sakaka, 72388, Aljouf, Saudi Arabia.
Inflammopharmacology ; 30(3): 945-959, 2022 Jun.
Article en En | MEDLINE | ID: mdl-35320496
Terpinen 4-ol, a phytochemical is a monoterpene which has been reported for its anti-inflammatory effect. Present research was planned to check its effect against arthritis through in vitro and in vivo models. Terpinen 4-ol was evaluated through in-vitro procedures including blocking of protein (BSA and egg albumin) denaturation and human RBC membrane stabilization. In in vivo study, terpinen 4-ol (15, 30 and 60 mg/kg) was evaluated using formaldehyde and CFA arthritic models. Terpinen 4-ol significantly inhibited increase in paw and joint swelling as compared to diseased group. Terpinen 4-ol showed remarkable antioxidant effect (SOD, reducing power) and also improved body weight, haematological, histopathological and radiological parameters in CFA model. Also, moreover, the excess production of IL-1ß, TNF-α, IRAK, and NF-kB were noticeably attenuated in all terpinen 4-ol treated rats, however, IL-17 and IL-10 were distinctly increased compared to arthritic control rats in RT-PCR. Also, terpinen 4-ol showed promising antioxidant effect in DPPH assay. Henceforth, it might be concluded that terpinen 4-ol has anti-arthritic effect which can be attributed to the downregulation of pro-inflammatory cytokines.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Experimental / Terpenos / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Inflammopharmacology Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2022 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Experimental / Terpenos / Antioxidantes Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Inflammopharmacology Asunto de la revista: FARMACOLOGIA / TERAPIA POR MEDICAMENTOS Año: 2022 Tipo del documento: Article País de afiliación: Pakistán Pais de publicación: Suiza