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Interleukin-10 Attenuates Behavioral, Immune and Neurotrophin Changes Induced by Chronic Central Administration of Interleukin-1ß in Rats.
Zhang, Yong-Ping; Li, Yu-Yu; Zhang, Cai; Li, Ya-Jun; Liu, Bai-Ping; Zhang, Yan; Lin, Ju-Da; Song, Cai.
Afiliación
  • Zhang YP; Institute for Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, China.
  • Li YY; Marine Medicine Research and Development Center of Shenzhen Institutes, Guangdong Ocean University, Shenzhen, China.
  • Zhang C; Institute for Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, China.
  • Li YJ; Institute for Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, China.
  • Liu BP; Institute for Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, China.
  • Zhang Y; Institute for Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, China.
  • Lin JD; Institute for Marine Drugs and Nutrition, College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, China.
  • Song C; Affiliated Hospital of Guangdong Medical University, Zhanjiang, China.
Neuroimmunomodulation ; 29(4): 380-390, 2022.
Article en En | MEDLINE | ID: mdl-35316814
BACKGROUND: Activated microglia can trigger pro-inflammatory cytokine releases and neuroinflammation, which may inhibit astrocytes to produce neurotrophins and anti-inflammatory factors. Both eventually lead to neuron apoptosis or death. Furthermore, effective antidepressant or anti-dementia treatments can reduce pro-inflammatory cytokines, while enhance interleukin (IL)-10 production. However, the underline mechanism by which IL-10 modulates glial cell function, hence improves cognitive impairment or depression-like behavior is unknown. This study evaluated whether and how IL-10 attenuated chronic IL-1ß administration-induced behavioral changes and the possible involved mechanisms. METHODS: Rats received intracerebroventricular injection of IL-1ß and/or IL-10 for 14 days. Then animal memory and depression-like behavior, pro-inflammatory cytokines, glial activities, expression of brain-derived neurotrophic factor (BDNF), Trk B, p75, and apoptosis-related genes were studied. RESULTS: Compared to controls, significantly increased latent time and swimming distance in the Morris-water-maze, decreased sucrose consumption, and decreased locomotor and center zone entries in the open-field were found in rats administrated with IL-1ß. These changes were associated with the reduction of GFAP expression, and concentrations of BDNF and anti-inflammatory cytokine IL-10, but the increase in the expressions of CD11b, TrkB, p75, and Caspase-3, the ratio of Bax/Bcl-2, and the concentrations of IL-1ß, tumor necrosis factor-α, and IL-6. IL-10 treatment markedly attenuated IL-1ß-induced above changes, except for the expressions of neurotrophin receptors. CONCLUSION: IL-10-improved behavioral changes may be through suppressing microglia activity and inflammation, while restoring astrocyte function and BDNF expression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Animal / Interleucina-10 / Factor Neurotrófico Derivado del Encéfalo / Interleucina-1beta Límite: Animals Idioma: En Revista: Neuroimmunomodulation Asunto de la revista: ALERGIA E IMUNOLOGIA / NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Conducta Animal / Interleucina-10 / Factor Neurotrófico Derivado del Encéfalo / Interleucina-1beta Límite: Animals Idioma: En Revista: Neuroimmunomodulation Asunto de la revista: ALERGIA E IMUNOLOGIA / NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza