[Electrophysiologic research on the anti-arrhythmia properties of bonnecor--a new dibenzazepine derivative]. / Elektrofiziologicheskoe issledovanie antiaritmicheskikh svoistv bonnekora--novogo proizvodnogo dibenzazepina.
Kardiologiia
; 26(8): 16-9, 1986 Aug.
Article
en Ru
| MEDLINE
| ID: mdl-3531669
A new dibenzepin derivative, bonnecor, showed marked antiarrhythmic and antifibrillation properties in anesthetized cats. One and 2 mg/kg doses of the drug reduce cardiac assimilation of imposed ventricular electric stimuli, increase ventricular fibrillation threshold with a strong and lasting effect and prevent arrhythmias and fibrillation due to 10-minute occlusion and subsequent reperfusion of the anterior descending branch of the left coronary artery. Experimental holding of atrial trabecular membrane potential in a frog, in conditions of a double saccharose bridge, showed bonnecor, in 5 X 10(-7) and 1 X 10(-6) g/ml concentrations, to inhibit rapid sodium inflow and slow calcium inflow. It is expected that bonnecor can be used clinically to control critical arrhythmias and prevent sudden cardiac death.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Dibenzazepinas
/
Antiarrítmicos
Límite:
Animals
Idioma:
Ru
Revista:
Kardiologiia
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Rusia