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Post-vaccination SARS-cov-2 infection in nursing home residents, Bordeaux, France.
Lartigau, Marion; Ouattara, Eric; Tumiotto, Camille; Wodrich, Harald; Busson, Laurent; Trimoulet, Pascale; Thiel, Elise; Nouzille, Mahissata; Dubos, Maria; Lafon, Marie-Edith; Gilleron, Véronique; Dehail, Patrick; Salles, Nathalie; Malvy, Denis.
Afiliación
  • Lartigau M; Department of Clinical Gerontology, University Hospital Centre Bordeaux, Bordeaux, France.
  • Ouattara E; Medical Information Department, Medical information Analysis and Coordination Unit (UCAIM-DIM), University Hospital Centre Bordeaux, Bordeaux, France. Electronic address: eric.ouattara@chu-bordeaux.fr.
  • Tumiotto C; Virology Laboratory, University Hospital Centre Bordeaux, Bordeaux, France; CNRS UMR5234, Fundamental Microbiology and Pathogenicity, University Hospital Centre Bordeaux, Bordeaux, France.
  • Wodrich H; CNRS UMR5234, Fundamental Microbiology and Pathogenicity, University Hospital Centre Bordeaux, Bordeaux, France.
  • Busson L; Virology Laboratory, University Hospital Centre Bordeaux, Bordeaux, France.
  • Trimoulet P; Virology Laboratory, University Hospital Centre Bordeaux, Bordeaux, France.
  • Thiel E; Department of Clinical Gerontology, University Hospital Centre Bordeaux, Bordeaux, France.
  • Nouzille M; Department of Clinical Gerontology, University Hospital Centre Bordeaux, Bordeaux, France.
  • Dubos M; Department of Clinical Gerontology, University Hospital Centre Bordeaux, Bordeaux, France.
  • Lafon ME; Virology Laboratory, University Hospital Centre Bordeaux, Bordeaux, France; CNRS UMR5234, Fundamental Microbiology and Pathogenicity, University Hospital Centre Bordeaux, Bordeaux, France.
  • Gilleron V; Medical Information Department, Medical information Analysis and Coordination Unit (UCAIM-DIM), University Hospital Centre Bordeaux, Bordeaux, France; Inserm U1219 / Bordeaux Population Health Research Center, Population Health trAnslational Research (PHARes), Universty of Bordeaux, Bordeaux, France
  • Dehail P; Inserm U1219 / IRD, University Hospital Centre Bordeaux, Bordeaux, France; Nouvelle-Aquitaine Regional Health Agency, Bordeaux, France.
  • Salles N; Department of Clinical Gerontology, University Hospital Centre Bordeaux, Bordeaux, France. Electronic address: nathalie.salles@chu-bordeaux.fr.
  • Malvy D; Department of Infectious Diseases and Tropical Medicine, Division of Tropical Medicine and Clinical International Health, University Hospital Centre Bordeaux, Bordeaux, France; Inserm U1219 / IRD, University Hospital Centre Bordeaux, Bordeaux, France.
J Clin Virol ; 149: 105134, 2022 04.
Article en En | MEDLINE | ID: mdl-35313222
OBJECTIVE: To describe COVID-19 breakthrough infections in two nursing homes (NHs) sites of active COVID-19 clusters despite optimal vaccination coverage. METHODS: A cross-sectional study was conducted in two NHs of south-western France, following the investigation of COVID-19 clusters (February-March 2021). SARS-CoV-2-confirmed infection was defined by positive RT-PCR. Antibodies neutralization capacities were tested in a subgroup of fully-vaccinated and seropositive-residents. RESULTS: Of the 152 residents, 66% were female with median age 87 years (IQR: 80.0-90.2). Overall, 132 (87%) residents received 2 doses of vaccine, 14 (9%) one dose and 6 (4%) were unvaccinated. Forty-seven (31%) residents had confirmed infection (45 (98%) with variant 20I/501Y.V1). All 6 non-vaccinated residents, 4 /14 who had one dose and 37/132 that had two doses, were infected. Of the 39 residents reporting symptoms, 12 and 3 presented severe and critical disease, respectively. One resident with a confirmed infection died. Infected-residents had a median anti-S IgG titre of 19 116.0 (IQR: 3 028.0-39 681.8 AU/mL), 19 times higher than that of non-infected vaccinated persons (1,207.0; IQR: 494.0-2,782.0). In the subgroup of 19 residents tested for neutralizing antibodies, the neutralizing titre (50%) was strongly positively correlated with the anti-S IgG titre (correlation coefficient = 0.83), and 1.5 times higher for the infected than non-infected residents [5.9 (IQR: 5.3-6.9) vs. 3.6 (2.9-3.8)]. CONCLUSION: Institutionalized elderly persons who undergo breakthrough infection develop higher titres of anti-S IgGs, which are strongly correlated with the neutralizing capacity of the antibodies. These results advocate for additional vaccine doses in this population.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / COVID-19 Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J Clin Virol Asunto de la revista: VIROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / COVID-19 Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J Clin Virol Asunto de la revista: VIROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Países Bajos