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Impact of Obstructive Sleep Apnea on Gestational Diabetes Mellitus.
Alonso-Fernández, Alberto; Cerdá Moncadas, María; Álvarez Ruiz De Larrinaga, Ainhoa; Sánchez Barón, Andrés; Codina Marcet, Mercedes; Rodríguez Rodríguez, Paula; Gil Gómez, Ana Victoria; Giménez Carrero, María P; Pía Martínez, Carla; Cubero Marín, José Pablo; de la Peña, Mónica; Barceló, Antonia; Morell-Garcia, Daniel; Pierola, Javier; Peña Zarza, José Antonio; Durán Cantolla, Joaquín; Marín Trigo, José María; Soriano, Joan B; García-Río, Francisco.
Afiliación
  • Alonso-Fernández A; Department of Pneumology, Hospital Universitario Son Espases, Palma de Mallorca, Spain; Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma de Mallorca, Spain; Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain. E
  • Cerdá Moncadas M; Department of Pneumology, Hospital de Manacor, Palma de Mallorca, Spain.
  • Álvarez Ruiz De Larrinaga A; Sleep Unit, Hospital Universitario de Araba, Vitoria, Spain; Instituto de Investigación BIOARABA, Vitoria, Spain.
  • Sánchez Barón A; Department of Pneumology, Hospital Universitario Miguel Servet, Zaragoza, Spain.
  • Codina Marcet M; Department of Endocrinology and metabolism, Hospital Universitario Son Espases, Palma de Mallorca, Spain.
  • Rodríguez Rodríguez P; Instituto de Investigación BIOARABA, Vitoria, Spain.
  • Gil Gómez AV; Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain.
  • Giménez Carrero MP; Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma de Mallorca, Spain.
  • Pía Martínez C; Instituto de Investigación BIOARABA, Vitoria, Spain.
  • Cubero Marín JP; Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain.
  • de la Peña M; Department of Pneumology, Hospital Universitario Son Espases, Palma de Mallorca, Spain; Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma de Mallorca, Spain; Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
  • Barceló A; Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma de Mallorca, Spain; Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Clinical Analysis, Hospital Universitario Son Espases, Palma de Mallorca, S
  • Morell-Garcia D; Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma de Mallorca, Spain; Department of Clinical Analysis, Hospital Universitario Son Espases, Palma de Mallorca, Spain.
  • Pierola J; Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma de Mallorca, Spain; Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
  • Peña Zarza JA; Institut d'Investigació Sanitària Illes Balears (IdISBa), Palma de Mallorca, Spain; Department of Pediatrics, Hospital Universitario Son Espases, Palma de Mallorca, Spain.
  • Durán Cantolla J; Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Sleep Unit, Hospital Universitario de Araba, Vitoria, Spain; Instituto de Investigación BIOARABA, Vitoria, Spain.
  • Marín Trigo JM; Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Pneumology, Hospital Universitario Miguel Servet, Zaragoza, Spain; Instituto de Investigación Sanitaria de Aragón, Zaragoza, Spain.
  • Soriano JB; Hospital Universitario de la Princesa-Universidad Autónoma de Madrid, Madrid, Spain.
  • García-Río F; Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Pneumology, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain.
Arch Bronconeumol ; 58(3): 219-227, 2022 Mar.
Article en En, Es | MEDLINE | ID: mdl-35312598
INTRODUCTION: Obstructive sleep apnea (OSA) increases the risk of type 2 diabetes, and hyperinsulinemia. Pregnancy increases the risk of OSA; however, the relationship between OSA and gestational diabetes mellitus (GDM) is unclear. We aimed (1) to evaluate OSA prevalence in GDM patients; (2) to assess the association between OSA and GDM; and (3) to determine the relationships between sleep parameters with insulin resistance (IR). METHODS: A total of 177 consecutive women (89 with GDM, 88 controls) in the third trimester of pregnancy underwent a hospital polysomnography. OSA was defined when the apnea-hypopnea index (AHI) was ≥5h-1. RESULTS: Patients with GDM had higher pregestational body mass index (BMI) and neck circumference than controls, but no differences in snoring or OSA-symptoms, or AHI (3.2±6.0 vs. 1.9±2.7h-1, p=.069). OSA prevalence was not significantly different in both groups. We did not identify OSA as a GDM risk factor in the crude analysis 1.65 (95%CI: 0.73-3.77; p=.232). Multiple regression showed that total sleep time (TST), TST spent with oxygen saturation<90% (T90), and maximum duration of respiratory events as independent factors related with homeostasis model assessment of IR, while T90 was the only independent determinant of quantitative insulin sensitivity check index. CONCLUSION: OSA prevalence during the third trimester of pregnancy was not significantly different in patients with GDM than without GDM, and no associations between OSA and GDM determinants were found. We identified T90 and obstructive respiratory events length positive-related to IR, while TST showed an inverse relationship with IR in pregnant women.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En / Es Revista: Arch Bronconeumol Año: 2022 Tipo del documento: Article Pais de publicación: España
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En / Es Revista: Arch Bronconeumol Año: 2022 Tipo del documento: Article Pais de publicación: España