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Multilayered 3-D nanofibrous scaffold with chondroitin sulfate sustained release as dermal substitute.
Sadeghi, Amin; Fatemi, Mohammad Javad; Zandi, Mojgan; Bagheri, Tooran; Ghadimi, Tayyeb; Tamimi, Maryam; Pezeshki-Modaress, Mohamad.
Afiliación
  • Sadeghi A; Soft Tissue Engineering Research Center, Tissue Engineering and Regenerative Medicine Institute, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
  • Fatemi MJ; Burn Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Plastic and Reconstructive Surgery, Hazrat Fatemeh Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Zandi M; Department of Biomaterials, Iran Polymer and Petrochemical Institute, Tehran, Iran.
  • Bagheri T; Burn Research Center, Iran University of Medical Sciences, Tehran, Iran.
  • Ghadimi T; Burn Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Plastic and Reconstructive Surgery, Hazrat Fatemeh Hospital, Iran University of Medical Sciences, Tehran, Iran.
  • Tamimi M; Hard Tissue Engineering Research Center, Tissue Engineering and Regenerative Medicine Institute, Central Tehran Branch, Islamic Azad University, Tehran, Iran.
  • Pezeshki-Modaress M; Burn Research Center, Iran University of Medical Sciences, Tehran, Iran; Stem Cell and Regenerative Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran. Electronic address: pezeshkimodaress.m@iums.ac.ir.
Int J Biol Macromol ; 206: 718-729, 2022 May 01.
Article en En | MEDLINE | ID: mdl-35304196
Electrospun nanofibers for skin tissue engineering applications face two main challenges. The low thickness of electrospun mats is the main reason for their weak load-bearing performance at clinical applications and limited cell penetration due to their small pore sizes. We have developed multi-layered nanofibrous 3D (M3DN) scaffolds comprising gelatin, polyvinyl alcohol, and chondroitin sulfate (CS) by an electrospinning method and attaching three electrospun layers via ethanol to cause interface fibers to come in contact with each other. Prepared M3DN scaffolds revealed a sustained CS release profile. The improved mechanical performance, stable release of CS, and penetration capability of the cells and blood vessels through the spaces between layers in the prepared multi-layered nanofibrous scaffolds demonstrate their potential applications in response to the increasing demand for replacement of damaged dermis. The results of animal studies on the dorsal skin of Rat with full-thickness wounds have shown that the reconstruction of full-thickness skin lesions is significantly higher for M3DN scaffolds than a control group (treated with sterile gauze). The amount of epithelization, collagen arrangement, and inflammatory cells (acute and chronic) has been investigated, and their associated results demonstrated that M3DN scaffolds have great potential for full-thickness wound restoration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanofibras Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nanofibras Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2022 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos