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The Impact of Injection Distance to Bifurcations on Yttrium-90 Distribution in Liver Cancer Radioembolization.
Taebi, Amirtahà; Janibek, Nursultan; Goldman, Roger; Pillai, Rex; Vu, Catherine T; Roncali, Emilie.
Afiliación
  • Taebi A; Department of Agricultural and Biological Engineering, Mississippi State University, Mississippi State, Mississippi. Electronic address: ataebi@abe.msstate.edu.
  • Janibek N; Department of Mechanical and Aerospace Engineering, University of California Davis, Davis, California.
  • Goldman R; Department of Radiology, University of California Davis, Sacramento, California.
  • Pillai R; Department of Radiology, University of California Davis, Sacramento, California.
  • Vu CT; Department of Radiology, University of California Davis, Sacramento, California.
  • Roncali E; Department of Radiology, University of California Davis, Sacramento, California; Department of Biomedical Engineering, University of California Davis, Davis, California.
J Vasc Interv Radiol ; 33(6): 668-677.e1, 2022 06.
Article en En | MEDLINE | ID: mdl-35301128
PURPOSE: To model the effect of the injection location on the distribution of yttrium-90 (90Y) microspheres in the liver during radioembolization using computational simulation and to determine the potential effects of radial movements of the catheter tip. MATERIALS AND METHODS: Numerical studies were conducted using images from a representative patient with hepatocellular carcinoma. The right hepatic artery (RHA) was segmented from contrast-enhanced cone-beam computed tomography scans. The blood flow was investigated in the trunk of the RHA using numerical simulations for 6 injection position scenarios at 2 sites located at a distance of approximately 5 and 20 mm upstream of the first bifurcation (RHA diameters of approximately 4.6 mm). The 90Y delivery to downstream vessels was calculated from the simulated hepatic artery hemodynamics. RESULTS: Varying the injection location along the RHA and across the vessel cross-section resulted in different simulated microsphere distributions in the downstream vascular bed. When the catheter tip was 5 mm upstream of the bifurcation, 90Y distribution in the downstream branches varied by as much as 53% with a 1.5-mm radial movement of the tip. However, the catheter radial movement had a weaker effect on the microsphere distribution when the injection plane was farther from the first bifurcation (20 mm), with a maximum delivery variation of 9% to a downstream branch. CONCLUSIONS: An injection location far from bifurcations is recommended to minimize the effect of radial movements of the catheter tip on the microsphere distribution.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Embolización Terapéutica / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: J Vasc Interv Radiol Asunto de la revista: ANGIOLOGIA / RADIOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma Hepatocelular / Embolización Terapéutica / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: J Vasc Interv Radiol Asunto de la revista: ANGIOLOGIA / RADIOLOGIA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos