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The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication.
Davarinejad, Hossein; Huang, Yi-Chun; Mermaz, Benoit; LeBlanc, Chantal; Poulet, Axel; Thomson, Geoffrey; Joly, Valentin; Muñoz, Marcelo; Arvanitis-Vigneault, Alexis; Valsakumar, Devisree; Villarino, Gonzalo; Ross, Alex; Rotstein, Benjamin H; Alarcon, Emilio I; Brunzelle, Joseph S; Voigt, Philipp; Dong, Jie; Couture, Jean-François; Jacob, Yannick.
Afiliación
  • Davarinejad H; Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
  • Huang YC; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.
  • Mermaz B; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.
  • LeBlanc C; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.
  • Poulet A; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.
  • Thomson G; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.
  • Joly V; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.
  • Muñoz M; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.
  • Arvanitis-Vigneault A; Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK.
  • Valsakumar D; Ottawa Institute of Systems Biology, Department of Biochemistry, Microbiology and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
  • Villarino G; BEaTS Research Laboratory, Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada.
  • Ross A; Department of Biochemistry, Microbiology, and Immunology, Faculty of Medicine, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.
  • Rotstein BH; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06511, USA.
  • Alarcon EI; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.
  • Brunzelle JS; Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK.
  • Voigt P; Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK.
  • Dong J; University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada.
  • Couture JF; Wellcome Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, UK.
  • Jacob Y; Epigenetics Programme, Babraham Institute, Cambridge CB22 3AT, UK.
Science ; 375(6586): 1281-1286, 2022 03 18.
Article en En | MEDLINE | ID: mdl-35298257
The tail of replication-dependent histone H3.1 varies from that of replication-independent H3.3 at the amino acid located at position 31 in plants and animals, but no function has been assigned to this residue to demonstrate a unique and conserved role for H3.1 during replication. We found that TONSOKU (TSK/TONSL), which rescues broken replication forks, specifically interacts with H3.1 via recognition of alanine 31 by its tetratricopeptide repeat domain. Our results indicate that genomic instability in the absence of ATXR5/ATXR6-catalyzed histone H3 lysine 27 monomethylation in plants depends on H3.1, TSK, and DNA polymerase theta (Pol θ). This work reveals an H3.1-specific function during replication and a common strategy used in multicellular eukaryotes for regulating post-replicative chromatin maturation and TSK, which relies on histone monomethyltransferases and reading of the H3.1 variant.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Histonas / Arabidopsis / ADN de Plantas / Proteínas de Arabidopsis / Reparación del ADN / Replicación del ADN Idioma: En Revista: Science Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Histonas / Arabidopsis / ADN de Plantas / Proteínas de Arabidopsis / Reparación del ADN / Replicación del ADN Idioma: En Revista: Science Año: 2022 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos