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Human periodontal ligament stem cells with distinct osteogenic potential induce bone formation in rat calvaria defects.
Adolpho, Leticia Faustino; Lopes, Helena Bacha; Freitas, Gileade Pereira; Weffort, Denise; Campos Totoli, Gabriela Guaraldo; Loyola Barbosa, Ana Carolina; Freire Assis, Rahyza Inacio; Silverio Ruiz, Karina Gonzales; Andia, Denise Carleto; Rosa, Adalberto Luiz; Beloti, Marcio Mateus.
Afiliación
  • Adolpho LF; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Av do Café, s/n, Ribeirão Preto, SP, 14040-904, Brazil.
  • Lopes HB; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Av do Café, s/n, Ribeirão Preto, SP, 14040-904, Brazil.
  • Freitas GP; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Av do Café, s/n, Ribeirão Preto, SP, 14040-904, Brazil.
  • Weffort D; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Av do Café, s/n, Ribeirão Preto, SP, 14040-904, Brazil.
  • Campos Totoli GG; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Av do Café, s/n, Ribeirão Preto, SP, 14040-904, Brazil.
  • Loyola Barbosa AC; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Av do Café, s/n, Ribeirão Preto, SP, 14040-904, Brazil.
  • Freire Assis RI; Department of Prosthodontics & Periodontics, Periodontics Division, Piracicaba Dental School, University of Campinas, Av Limeira, 901, Piracicaba, SP, 13414-903, Brazil.
  • Silverio Ruiz KG; Department of Prosthodontics & Periodontics, Periodontics Division, Piracicaba Dental School, University of Campinas, Av Limeira, 901, Piracicaba, SP, 13414-903, Brazil.
  • Andia DC; Health Science Institute, Dental Research Division, Paulista University, Dr Bacelar St, 1212, São Paulo, SP, 04026-002, Brazil.
  • Rosa AL; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Av do Café, s/n, Ribeirão Preto, SP, 14040-904, Brazil.
  • Beloti MM; Bone Research Lab, School of Dentistry of Ribeirão Preto, University of São Paulo, Av do Café, s/n, Ribeirão Preto, SP, 14040-904, Brazil.
Regen Med ; 17(6): 341-353, 2022 06.
Article en En | MEDLINE | ID: mdl-35291805
Bone is one of the most transplanted tissues worldwide and cell-based therapies has been investigated as an alternative for the treatment of bone defects. Dental tissues have been investigated as sources of stem cells and the periodontal ligament has been shown to be a viable source of these cells. Stem cells from periodontal ligament induce significant bone formation in rat calvaria defects and are safe for cell-based therapies, as the cells remain at the bone defect site for up to 4 weeks and do not migrate to vital organs, such as brain, heart, lungs, spleen, kidneys, and liver in the same period. In addition, immune responses were not detected. Considering that, stem cells from periodontal ligament can be useful in cell therapy strategies to induce bone regeneration.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteogénesis / Ligamento Periodontal Límite: Animals / Humans Idioma: En Revista: Regen Med Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Osteogénesis / Ligamento Periodontal Límite: Animals / Humans Idioma: En Revista: Regen Med Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido