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C1q+ macrophages: passengers or drivers of cancer progression.
Revel, Margot; Sautès-Fridman, Catherine; Fridman, Wolf-Herman; Roumenina, Lubka T.
Afiliación
  • Revel M; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, F-75006 Paris, France.
  • Sautès-Fridman C; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, F-75006 Paris, France.
  • Fridman WH; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, F-75006 Paris, France.
  • Roumenina LT; Centre de Recherche des Cordeliers, INSERM, Sorbonne Université, Université de Paris, F-75006 Paris, France. Electronic address: lubka.roumenina@sorbonne-universite.fr.
Trends Cancer ; 8(7): 517-526, 2022 07.
Article en En | MEDLINE | ID: mdl-35288093
The omics era made possible the quest for efficient markers for cancer progression and revealed that macrophage populations are much more complex than just the M1/M2 dichotomy. Complement C1q pops up as a marker of a tolerogenic and immunosuppressive macrophage populations in both healthy and tumor tissues, but the specific role of C1q+ tumor-associated macrophages (TAM) is poorly understood. C1q is co-expressed in healthy and tumor macrophages with human leukocyte antigen DR (HLA-DR), Apolipoprotein E (APOE), and mannose receptor C-type 1 (MRC1) (CD206), suggesting a resident origin of this population. TAM expressing C1q correlate with T cell exhaustion and poor prognosis in numerous cancers. Herein, we discuss the plural roles of C1q in these macrophages and how it could drive cancer progression.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complemento C1q / Neoplasias Límite: Humans Idioma: En Revista: Trends Cancer Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complemento C1q / Neoplasias Límite: Humans Idioma: En Revista: Trends Cancer Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Estados Unidos