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Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe.
Tamayo, Nuria A; Bourbeau, Matthew P; Allen, Jennifer R; Ashton, Kate S; Chen, Jian Jeffrey; Kaller, Matthew R; Nguyen, Thomas T; Nishimura, Nobuko; Pettus, Liping H; Walton, Mary; Belmontes, Brian; Moriguchi, Jodi; Chen, Kui; McCarter, John D; Hanestad, Kelly; Chung, Grace; Ninniri, Maria Stefania S; Sun, Jan; Poppe, Leszek; Spahr, Chris; Hui, John; Jia, Lei; Wu, Tian; Dahal, Upendra P; Edson, Katheryne Z; Payton, Marc.
Afiliación
  • Tamayo NA; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Bourbeau MP; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Allen JR; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Ashton KS; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Chen JJ; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Kaller MR; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Nguyen TT; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Nishimura N; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Pettus LH; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Walton M; Medicinal Chemistry, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Belmontes B; Oncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Moriguchi J; Oncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Chen K; Discovery Technologies, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • McCarter JD; Discovery Technologies, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Hanestad K; Oncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Chung G; Oncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Ninniri MSS; Oncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Sun J; Oncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Poppe L; Discovery Attribute Sciences, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Spahr C; Discovery Attribute Sciences, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Hui J; Discovery Attribute Sciences, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Jia L; Computational & Data Sciences, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Wu T; Pre-Pivotal Drug Product, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Dahal UP; Pharmacokinetics and Drug Metabolism, Amgen Research, 1120 Veterans Blvd., South San Francisco, California 94080, United States.
  • Edson KZ; Pharmacokinetics and Drug Metabolism, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
  • Payton M; Oncology Research, Amgen Research, One Amgen Center Drive, Thousand Oaks, California 91320, United States.
J Med Chem ; 65(6): 4972-4990, 2022 03 24.
Article en En | MEDLINE | ID: mdl-35286090
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cinesinas / Neoplasias Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cinesinas / Neoplasias Límite: Humans Idioma: En Revista: J Med Chem Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos