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Role and Mechanism of lncRNA-pvt1 in the Pathogenesis of Acute Lymphoblastic Leukemia in Children.
Cheng, Yanli; Hao, Guoping; Wang, Xiaohuan; Lu, Haiyan; Wang, Jing; Suo, Taoli; Hou, Zhaohui; Guo, Huimin; Zhang, Shixun.
Afiliación
  • Cheng Y; Department of Hematology, Shanxi Children's Hospital, China.
  • Hao G; Department of Hematology, Shanxi Children's Hospital, China.
  • Wang X; Department of Hematology, Shanxi Children's Hospital, China.
  • Lu H; Department of Hematology, Shanxi Children's Hospital, China.
  • Wang J; Department of Hematology, Shanxi Children's Hospital, China.
  • Suo T; Department of Hematology, Shanxi Children's Hospital, China.
  • Hou Z; Department of Hematology, Shanxi Children's Hospital, China.
  • Guo H; Scientific Research Department of Clinical Laboratory Center of Shanxi Children's Hospital, China.
  • Zhang S; Bone Marrow Laboratory of Shanxi Children's Hospital, China.
Comput Math Methods Med ; 2022: 8955322, 2022.
Article en En | MEDLINE | ID: mdl-35281949
Objective: To investigate the role and mechanism of lncRNA-pvt1 in the pathogenesis of childhood acute lymphoblastic leukemia (ALL). Methods: The expression of lncRNA-pvt1 in bone marrow tissues of ALL patients after initial diagnosis and complete remission was detected by RT-PCR to explore its possible involvement in the pathogenesis of ALL. The proliferation and apoptosis of Jurkat cells transfected with lncRNA-pvt1 were observed by MTT and flow cytometry. Results: lncRNA-pvt1 expression was upregulated in bone marrow of ALL patients. Knockdown of lncRNA-pvt1 inhibited Jurkat cell proliferation and increased its apoptosis rate. Conclusion: Silencing lncRNA-pvt1 expression can inhibit the development of ALL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / ARN Largo no Codificante Tipo de estudio: Etiology_studies / Observational_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Comput Math Methods Med Asunto de la revista: INFORMATICA MEDICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / ARN Largo no Codificante Tipo de estudio: Etiology_studies / Observational_studies Límite: Child / Child, preschool / Female / Humans / Male Idioma: En Revista: Comput Math Methods Med Asunto de la revista: INFORMATICA MEDICA Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos