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A Comprehensive Pan-Cancer Analysis for Pituitary Tumor-Transforming Gene 1.
Gong, Siming; Wu, Changwu; Duan, Yingjuan; Tang, Juyu; Wu, Panfeng.
Afiliación
  • Gong S; Department of Orthopaedics, National Clinical Research Center of Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, China.
  • Wu C; Institute of Anatomy, University of Leipzig, Leipzig, Germany.
  • Duan Y; Institute of Anatomy, University of Leipzig, Leipzig, Germany.
  • Tang J; Faculty of Chemistry and Mineralogy, University of Leipzig, Leipzig, Germany.
  • Wu P; Department of Orthopaedics, National Clinical Research Center of Geriatric Disorders, Xiangya Hospital of Central South University, Changsha, China.
Front Genet ; 13: 843579, 2022.
Article en En | MEDLINE | ID: mdl-35281830
Pituitary tumor-transforming gene 1 (PTTG1) encodes a multifunctional protein that is involved in many cellular processes. However, the potential role of PTTG1 in tumor formation and its prognostic function in human pan-cancer is still unknown. The analysis of gene alteration, PTTG1 expression, prognostic function, and PTTG1-related immune analysis in 33 types of tumors was performed based on various databases such as The Cancer Genome Atlas database, the Genotype-Tissue Expression database, and the Human Protein Atlas database. Additionally, PTTG1-related gene enrichment analysis was performed to investigate the potential relationship and possible molecular mechanisms between PTTG1 and tumors. Overexpression of PTTG1 may lead to tumor formation and poor prognosis in various tumors. Consequently, PTTG1 acts as a potential oncogene in most tumors. Additionally, PTTG1 is related to immune infiltration, immune checkpoints, tumor mutational burden, and microsatellite instability. Thus, PTTG1 could be potential biomarker for both prognosis and outcomes of tumor treatment and it could also be a promising target in tumor therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Genet Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Genet Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza