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Calcium Signaling Regulated by Cellular Membrane Systems and Calcium Homeostasis Perturbed in Alzheimer's Disease.
Huang, Dong-Xu; Yu, Xin; Yu, Wen-Jun; Zhang, Xin-Min; Liu, Chang; Liu, Hong-Ping; Sun, Yue; Jiang, Zi-Ping.
Afiliación
  • Huang DX; Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, China.
  • Yu X; Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, China.
  • Yu WJ; Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, China.
  • Zhang XM; Department of Anesthesiology, The First Hospital of Jilin University, Changchun, China.
  • Liu C; Department of Neurology, The First Hospital of Jilin University, Changchun, China.
  • Liu HP; Department of Neurology, The First Hospital of Jilin University, Changchun, China.
  • Sun Y; Deparment of The First Operating Room, The First Hospital of Jilin University, Changchun, China.
  • Jiang ZP; Department of Hand and Foot Surgery, The First Hospital of Jilin University, Changchun, China.
Front Cell Dev Biol ; 10: 834962, 2022.
Article en En | MEDLINE | ID: mdl-35281104
Although anything that changes spatiotemporally could be a signal, cells, particularly neurons, precisely manipulate calcium ion (Ca2+) to transmit information. Ca2+ homeostasis is indispensable for neuronal functions and survival. The cytosolic Ca2+ concentration ([Ca2+]CYT) is regulated by channels, pumps, and exchangers on cellular membrane systems. Under physiological conditions, both endoplasmic reticulum (ER) and mitochondria function as intracellular Ca2+ buffers. Furthermore, efficient and effective Ca2+ flux is observed at the ER-mitochondria membrane contact site (ERMCS), an intracellular membrane juxtaposition, where Ca2+ is released from the ER followed by mitochondrial Ca2+ uptake in sequence. Hence, the ER intraluminal Ca2+ concentration ([Ca2+]ER), the mitochondrial matrix Ca2+ concentration ([Ca2+]MT), and the [Ca2+]CYT are related to each other. Ca2+ signaling dysregulation and Ca2+ dyshomeostasis are associated with Alzheimer's disease (AD), an irreversible neurodegenerative disease. The present review summarizes the cellular and molecular mechanism underlying Ca2+ signaling regulation and Ca2+ homeostasis maintenance at ER and mitochondria levels, focusing on AD. Integrating the amyloid hypothesis and the calcium hypothesis of AD may further our understanding of pathogenesis in neurodegeneration, provide therapeutic targets for chronic neurodegenerative disease in the central nervous system.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza