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Touch and Go: Membrane Contact Sites Between Lipid Droplets and Other Organelles.
Liao, Pin-Chao; Yang, Emily J; Borgman, Taylor; Boldogh, Istvan R; Sing, Cierra N; Swayne, Theresa C; Pon, Liza A.
Afiliación
  • Liao PC; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, United States.
  • Yang EJ; Institute of Molecular Medicine, National Tsing Hua University, Hsinchu, Taiwan.
  • Borgman T; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, United States.
  • Boldogh IR; Institute of Human Nutrition, Columbia University Irving Medical Center, New York, NY, United States.
  • Sing CN; Department of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, United States.
  • Swayne TC; Herbert Irving Comprehensive Cancer Center, Columbia University Irving Medical Center, New York, NY, United States.
  • Pon LA; Institute of Human Nutrition, Columbia University Irving Medical Center, New York, NY, United States.
Front Cell Dev Biol ; 10: 852021, 2022.
Article en En | MEDLINE | ID: mdl-35281095
Lipid droplets (LDs) have emerged not just as storage sites for lipids but as central regulators of metabolism and organelle quality control. These critical functions are achieved, in part, at membrane contact sites (MCS) between LDs and other organelles. MCS are sites of transfer of cellular constituents to or from LDs for energy mobilization in response to nutrient limitations, as well as LD biogenesis, expansion and autophagy. Here, we describe recent findings on the mechanisms underlying the formation and function of MCS between LDs and mitochondria, ER and lysosomes/vacuoles and the role of the cytoskeleton in promoting LD MCS through its function in LD movement and distribution in response to environmental cues.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Cell Dev Biol Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza