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Efficacy of EPA-registered disinfectants against two human norovirus surrogates and Clostridioides difficile endospores.
Huang, Jinge; Park, Geun Woo; Jones, Rachael M; Fraser, Angela M; Vinjé, Jan; Jiang, Xiuping.
Afiliación
  • Huang J; Department of Food, Nutrition, and Packaging Sciences, Clemson University, Clemson, South Carolina, USA.
  • Park GW; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Jones RM; Department of Family and Preventive Medicine, University of Utah, Salt Lake City, Utah, USA.
  • Fraser AM; Department of Food, Nutrition, and Packaging Sciences, Clemson University, Clemson, South Carolina, USA.
  • Vinjé J; Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Jiang X; Department of Food, Nutrition, and Packaging Sciences, Clemson University, Clemson, South Carolina, USA.
J Appl Microbiol ; 132(6): 4289-4299, 2022 Jun.
Article en En | MEDLINE | ID: mdl-35279925
AIMS: To determine the efficacy of a panel of nine EPA-registered disinfectants against two human norovirus (HuNoV) surrogates (feline calicivirus [FCV] and Tulane virus [TuV]) and Clostridioides difficile endospores. METHODS AND RESULTS: Nine EPA-registered products, five of which contained H2 O2 as active ingredient, were tested against infectious FCV, TuV and C. difficile endospores using two ASTM methods, a suspension and carrier test. Efficacy claims against FCV were confirmed for 8 of 9 products. The most efficacious product containing H2 O2 as ingredient achieved a >5.1 log reduction of FCV and >3.1 log reduction of TuV after 5 min, and >6.0 log reduction of C. difficile endospores after 10 min. Of the five products containing H2 O2 , no strong correlation (R2  = 0.25, p = 0.03) was observed between disinfection efficacy and H2 O2 concentration. Addition of 0.025% ferrous sulphate to 1% H2 O2 solution improved efficacy against FCV, TuV and C. difficile. CONCLUSION: Disinfectants containing H2 O2 are the most efficacious disinfection products against FCV, TuV and C. difficile endospores. Product formulation, rather than the concentration of H2 O2 in a product, impacts the efficacy of a disinfection product. SIGNIFICANCE AND IMPACT OF STUDY: H2 O2 -based disinfectants are efficacious against surrogate viruses for HuNoV and C. difficile endospores.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Clostridioides difficile / Calicivirus Felino / Norovirus / Desinfectantes Límite: Animals / Humans Idioma: En Revista: J Appl Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Clostridioides difficile / Calicivirus Felino / Norovirus / Desinfectantes Límite: Animals / Humans Idioma: En Revista: J Appl Microbiol Asunto de la revista: MICROBIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido