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Monitoring IgG against Mycobacterium tuberculosis proteins in an Asian elephant cured of tuberculosis that developed from long-term latency.
Ishikawa, Satoshi; Ozeki, Yuriko; Suga, Satomi; Mukai, Yasuhiko; Kobayashi, Haruka; Inouchi, Erina; Kaboso, Shaban A; Gebretsadik, Gebremichal; Dewi, Desak Nyoman Surya Suameitria; Nishiyama, Akihito; Tateishi, Yoshitaka; Takihara, Hayato; Okuda, Shujiro; Yoshida, Shiomi; Misawa, Naoaki; Matsumoto, Sohkichi.
Afiliación
  • Ishikawa S; Department of Bacteriology, Niigata University School of Medicine, 1-757, Asahimachi-Dori, Chuo-ku, Niigata, Niigata, 951-9510, Japan. sat.ishikawa@kyf.biglobe.ne.jp.
  • Ozeki Y; Fukuyama Zoo, 276-1, Fukuda, Ashida-cho, Fukuyama, Hiroshima, 720-1264, Japan. sat.ishikawa@kyf.biglobe.ne.jp.
  • Suga S; Department of Bacteriology, Niigata University School of Medicine, 1-757, Asahimachi-Dori, Chuo-ku, Niigata, Niigata, 951-9510, Japan.
  • Mukai Y; Fukuyama Zoo, 276-1, Fukuda, Ashida-cho, Fukuyama, Hiroshima, 720-1264, Japan.
  • Kobayashi H; Fukuyama Zoo, 276-1, Fukuda, Ashida-cho, Fukuyama, Hiroshima, 720-1264, Japan.
  • Inouchi E; Department of Bacteriology, Niigata University School of Medicine, 1-757, Asahimachi-Dori, Chuo-ku, Niigata, Niigata, 951-9510, Japan.
  • Kaboso SA; Department of Bacteriology, Niigata University School of Medicine, 1-757, Asahimachi-Dori, Chuo-ku, Niigata, Niigata, 951-9510, Japan.
  • Gebretsadik G; Department of Bacteriology, Niigata University School of Medicine, 1-757, Asahimachi-Dori, Chuo-ku, Niigata, Niigata, 951-9510, Japan.
  • Dewi DNSS; Department of Bacteriology, Niigata University School of Medicine, 1-757, Asahimachi-Dori, Chuo-ku, Niigata, Niigata, 951-9510, Japan.
  • Nishiyama A; Department of Bacteriology, Niigata University School of Medicine, 1-757, Asahimachi-Dori, Chuo-ku, Niigata, Niigata, 951-9510, Japan.
  • Tateishi Y; Department of Microbiology, Faculty of Medicine, Universitas Ciputra, CitraLand CBD Boulevard, Made, Sambikerep, Surabaya, 60219, Indonesia.
  • Takihara H; Department of Bacteriology, Niigata University School of Medicine, 1-757, Asahimachi-Dori, Chuo-ku, Niigata, Niigata, 951-9510, Japan.
  • Okuda S; Department of Bacteriology, Niigata University School of Medicine, 1-757, Asahimachi-Dori, Chuo-ku, Niigata, Niigata, 951-9510, Japan.
  • Yoshida S; Division of Bioinformatics, Niigata University Graduate School of Medical and Dental Sciences, 2-5274, Gakkocho-dori, Chuo-ku, Niigata, Niigata, 951-8514, Japan.
  • Misawa N; Division of Bioinformatics, Niigata University Graduate School of Medical and Dental Sciences, 2-5274, Gakkocho-dori, Chuo-ku, Niigata, Niigata, 951-8514, Japan.
  • Matsumoto S; Medical AI Center, Niigata University School of Medicine, 2-5274, Gakkocho-dori, Chuo-ku, Niigata, Niigata, 951-8514, Japan.
Sci Rep ; 12(1): 4310, 2022 03 12.
Article en En | MEDLINE | ID: mdl-35279668
Tuberculosis (TB) is fatal in elephants, hence protecting elephants from TB is key not only in the conservation of this endangered animal, but also to prevent TB transmission from elephants to humans. Most human TB cases arise from long-term asymptomatic infections. Significant diagnostic challenges remain in the detection of both infection and disease development from latency in elephants due to their huge bodies. In this study, we assessed cryopreserved sera collected for over 16 years, from the first Japanese treatment case of elephant TB. Semi-quantification of IgG levels to 11 proteins showed high detection levels of 3 proteins, namely ESAT6/CFP10, MPB83 and Ag85B. The level of IgG specific to these 3 antigens was measured longitudinally, revealing high and stable ESAT6/CFP10 IgG levels regardless of onset or treatment. Ag85B-specifc IgG levels were largely responsive to onset or treatment, while those of MPB83 showed intermediate responses. These results suggest that ESAT6/CFP10 is immunodominant in both asymptomatic and symptomatic phases, making it useful in the detection of infection. On the other hand, Ag85B has the potential to be a marker for the prediction of disease onset and in the evaluation of treatment effectiveness in elephants.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Elefantes / Mycobacterium tuberculosis Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Elefantes / Mycobacterium tuberculosis Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Sci Rep Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido