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Higher white matter hyperintensity load adversely affects pre-post proximal cognitive training performance in healthy older adults.
Boutzoukas, Emanuel M; O'Shea, Andrew; Kraft, Jessica N; Hardcastle, Cheshire; Evangelista, Nicole D; Hausman, Hanna K; Albizu, Alejandro; Van Etten, Emily J; Bharadwaj, Pradyumna K; Smith, Samantha G; Song, Hyun; Porges, Eric C; Hishaw, Alex; DeKosky, Steven T; Wu, Samuel S; Marsiske, Michael; Alexander, Gene E; Cohen, Ronald; Woods, Adam J.
Afiliación
  • Boutzoukas EM; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
  • O'Shea A; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
  • Kraft JN; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
  • Hardcastle C; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
  • Evangelista ND; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA.
  • Hausman HK; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
  • Albizu A; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
  • Van Etten EJ; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
  • Bharadwaj PK; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
  • Smith SG; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
  • Song H; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
  • Porges EC; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
  • Hishaw A; Department of Neuroscience, College of Medicine, University of Florida, Gainesville, FL, USA.
  • DeKosky ST; Department of Psychology and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA.
  • Wu SS; Department of Psychology and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA.
  • Marsiske M; Department of Psychology and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA.
  • Alexander GE; Department of Psychology and Evelyn F. McKnight Brain Institute, University of Arizona, Tucson, AZ, USA.
  • Cohen R; Center for Cognitive Aging and Memory, McKnight Brain Institute, University of Florida, Gainesville, FL, USA.
  • Woods AJ; Department of Clinical and Health Psychology, College of Public Health and Health Professions, University of Florida, Gainesville, FL, USA.
Geroscience ; 44(3): 1441-1455, 2022 06.
Article en En | MEDLINE | ID: mdl-35278154
Cognitive training has shown promise for improving cognition in older adults. Age-related neuroanatomical changes may affect cognitive training outcomes. White matter hyperintensities are one common brain change in aging reflecting decreased white matter integrity. The current study assessed (1) proximal cognitive training performance following a 3-month randomized control trial and (2) the contribution of baseline whole-brain white matter hyperintensity load, or total lesion volume (TLV), on pre-post proximal training change. Sixty-two healthy older adults were randomized to either adaptive cognitive training or educational training control interventions. Repeated-measures analysis of covariance revealed two-way group × time interactions such that those assigned cognitive training demonstrated greater improvement on proximal composite (total training composite) and sub-composite (processing speed training composite, working memory training composite) measures compared to education training counterparts. Multiple linear regression showed higher baseline TLV associated with lower pre-post change on processing speed training sub-composite (ß = -0.19, p = 0.04), but not other composite measures. These findings demonstrate the utility of cognitive training for improving post-intervention proximal performance in older adults. Additionally, pre-post proximal processing speed training change appears to be particularly sensitive to white matter hyperintensity load versus working memory training change. These data suggest that TLV may serve as an important factor for consideration when planning processing speed-based cognitive training interventions for remediation of cognitive decline in older adults.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos del Conocimiento / Disfunción Cognitiva / Sustancia Blanca Tipo de estudio: Clinical_trials Límite: Aged / Humans Idioma: En Revista: Geroscience Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos del Conocimiento / Disfunción Cognitiva / Sustancia Blanca Tipo de estudio: Clinical_trials Límite: Aged / Humans Idioma: En Revista: Geroscience Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Suiza