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Simple and simultaneous quantification of cyanide, ethanol, and 1-propanol in blood by headspace GC-MS/NPD with Deans switch dual detector system.
Saka, Kanju; Kudo, Keiko; Namera, Akira; Fujii, Yusuke; Noritake, Kanako; Torimitsu, Suguru; Makino, Yohsuke; Iwase, Hirotaro.
Afiliación
  • Saka K; Department of Forensic Medicine, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: kanju@m.u-tokyo.ac.jp.
  • Kudo K; Fukuoka University Research Institute for Toxicological Detection and Monitoring, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.
  • Namera A; Department of Forensic Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima City, Hiroshima 734-8553, Japan.
  • Fujii Y; Department of Forensic Medicine, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Noritake K; Department of Forensic Medicine, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Torimitsu S; Department of Forensic Medicine, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Makino Y; Department of Forensic Medicine, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Iwase H; Department of Forensic Medicine, Graduate School of Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Department of Legal Medicine, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba City, Chiba 260-8670, Japan.
Sci Justice ; 62(2): 193-202, 2022 03.
Article en En | MEDLINE | ID: mdl-35277233
Cyanide is a powerful and rapidly acting poison. In Japan, cyanide poisoning is rare, and regular cyanide testing can be costly and time consuming. In contrast, alcohol analysis is routinely performed in most forensic laboratories. In this study, we attempted to develop a method for the simultaneous quantification of cyanide and alcohols in blood using headspace gas chromatography (HS-GC). As nitrogen-phosphorus detection (NPD) is more sensitive to hydrogen cyanide than mass spectrometry (MS), a Deans switch was used to switch the detectors during a single run. The separation provided by three analytical columns, PoraBOND Q, CP-Sil 5 CB, and HP-INNOWax, was investigated, and PoraBOND Q was selected. The use of HS-GC-MS/NPD with a Deans switch enabled the simple and simultaneous quantification of cyanide, ethanol, and 1-propanol. Eighteen other volatile compounds were detected in the SIM/scan mode of the MS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cianuros / 1-Propanol Límite: Humans Idioma: En Revista: Sci Justice Asunto de la revista: JURISPRUDENCIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cianuros / 1-Propanol Límite: Humans Idioma: En Revista: Sci Justice Asunto de la revista: JURISPRUDENCIA Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido