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Long-Term Consumption of a Sugar-Sweetened Soft Drink in Combination with a Western-Type Diet Is Associated with Morphological and Molecular Changes of Taste Markers Independent of Body Weight Development in Mice.
Lieder, Barbara; Conka, Jozef; Reiner, Agnes T; Zabel, Victoria; Ameur, Dominik; Somoza, Mark M; Sebeková, Katarína; Celec, Peter; Somoza, Veronika.
Afiliación
  • Lieder B; Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.
  • Conka J; Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 81101 Bratislava, Slovakia.
  • Reiner AT; Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.
  • Zabel V; Department of Physiological Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.
  • Ameur D; Department of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.
  • Somoza MM; Department of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, 1090 Vienna, Austria.
  • Sebeková K; Leibniz Institute for Food Systems Biology at the Technical University of Munich, 85345 Freising, Germany.
  • Celec P; Food Chemistry and Molecular Sensory Science, Technical University of Munich, 85345 Freising, Germany.
  • Somoza V; Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, 81101 Bratislava, Slovakia.
Nutrients ; 14(3)2022 Jan 29.
Article en En | MEDLINE | ID: mdl-35276952
We investigated whether the long-term intake of a typical sugar-sweetened soft drink (sugar-sweetened beverage, SSB) alters markers for taste function when combined with a standard diet (chow) or a model chow mimicking a Western diet (WD). Adult male CD1 mice had ad libitum access to tap water or SSB in combination with either the chow or the WD for 24 weeks. Energy intake from fluid and food was monitored three times a week. Cardiometabolic markers (body weight and composition, waist circumference, glucose and lipid profile, and blood pressure) were analyzed at the end of the intervention, as was the number and size of the fungiform papillae as well as mRNA levels of genes associated with the different cell types of taste buds and taste receptors in the circumvallate papillae using a cDNA microarray and qPCR. Although the overall energy intake was higher in the WD groups, there was no difference in body weight or other cardiometabolic markers between the SSB and water groups. The chemosensory surface from the fungiform papillae was reduced by 36 ± 19% (p < 0.05) in the WD group after SSB compared to water intake. In conclusion, the consumption of the SSB reduced the chemosensory surface of the fungiform papillae of CD1 mice when applied in combination with a WD independent of body weight. The data suggest synergistic effects of a high sugar-high fat diet on taste dysfunction, which could further influence food intake and promote a vicious cycle of overeating and taste dysfunction.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dieta Occidental / Bebidas Azucaradas Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Nutrients Año: 2022 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dieta Occidental / Bebidas Azucaradas Tipo de estudio: Risk_factors_studies Límite: Animals Idioma: En Revista: Nutrients Año: 2022 Tipo del documento: Article País de afiliación: Austria Pais de publicación: Suiza