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The Body Fat Percentage Rather Than the BMI Is Associated with the CD4 Count among HIV Positive Japanese Individuals.
Shoji, Kumiko; Shirano, Michinori; Konishi, Mitsuru; Toyoshima, Yuko; Matsumoto, Miyuki; Goto, Tetsushi; Kasamatsu, Yu; Ichida, Yuji; Kagawa, Yasuo; Kawabata, Terue; Ogata, Hiromitsu; Habu, Daiki.
Afiliación
  • Shoji K; Faculty of Nutrition, Kagawa Nutrition University, Saitama 350-0288, Japan.
  • Shirano M; Department of Infectious Disease, Osaka City General Hospital, Osaka 534-0021, Japan.
  • Konishi M; Center for Health Control, Nara Medical University, Nara 634-8521, Japan.
  • Toyoshima Y; Department of Nursing, Osaka City General Hospital, Osaka 534-0021, Japan.
  • Matsumoto M; Kurokawa Clinic, Osaka 557-0031, Japan.
  • Goto T; Department of Infectious Disease, Osaka City General Hospital, Osaka 534-0021, Japan.
  • Kasamatsu Y; Department of Infectious Disease, Osaka City General Hospital, Osaka 534-0021, Japan.
  • Ichida Y; Department of Infectious Disease, University Hospital, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan.
  • Kagawa Y; Department of Pharmacy, Osaka City General Hospital, Osaka 534-0021, Japan.
  • Kawabata T; Faculty of Nutrition, Kagawa Nutrition University, Saitama 350-0288, Japan.
  • Ogata H; Faculty of Nutrition, Kagawa Nutrition University, Saitama 350-0288, Japan.
  • Habu D; Faculty of Nutrition, Kagawa Nutrition University, Saitama 350-0288, Japan.
Nutrients ; 14(3)2022 Jan 18.
Article en En | MEDLINE | ID: mdl-35276785
Maintenance of the cluster of differentiation 4 (CD4) positive lymphocyte count (CD4 count) is important for human immunodeficiency virus (HIV) positive individuals. Although a higher body mass index (BMI) is shown to be associated with a higher CD4 count, BMI itself does not reflect body composition. Therefore, we examined the association of body weight, body composition and the CD4 count, and determined the optimal ranges of CD4 count associated factors in Japanese HIV positive individuals. This cross-sectional study included 338 male patients treated with antiretroviral therapy for ≥12 months. Multiple logistic regression analysis was used to identify factors significantly associated with a CD4 count of ≥500 cells (mm3)-1. The cutoff values of factors for a CD4 ≥ 500 cells (mm3)-1 and cardiovascular disease risk were obtained by receiver operating characteristic curves. Age, body fat percentage (BF%), nadir CD4 count, duration of antiretroviral therapy (ART), years since the HIV-positive diagnosis and cholesterol intake showed significant associations with the CD4 count. The cutoff value of BF% for a CD4 ≥ 500 cells (mm3)-1 and lower cardiovascular disease risk were ≥25.1% and ≤25.5%, respectively. The BF%, but not the BMI, was associated with CD4 count. For the management of HIV positive individuals, 25% appears to be the optimal BF% when considering the balance between CD4 count management and cardiovascular disease risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male País/Región como asunto: Asia Idioma: En Revista: Nutrients Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Infecciones por VIH Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Male País/Región como asunto: Asia Idioma: En Revista: Nutrients Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza