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Efficient TGF-ß1 Delivery to Articular Chondrocytes In Vitro Using Agro-Based Liposomes.
Velot, Émilie; Elkhoury, Kamil; Kahn, Cyril; Kempf, Hervé; Linder, Michel; Arab-Tehrany, Elmira; Bianchi, Arnaud.
Afiliación
  • Velot É; IMoPA (Molecular Engineering and Articular Physiopathology), CNRS (French National Centre for Scientific Research), Université de Lorraine, F-54000 Nancy, France.
  • Elkhoury K; LIBio (Laboratoire d'Ingénierie des Biomolécules), Université de Lorraine, F-54000 Nancy, France.
  • Kahn C; LIBio (Laboratoire d'Ingénierie des Biomolécules), Université de Lorraine, F-54000 Nancy, France.
  • Kempf H; IMoPA (Molecular Engineering and Articular Physiopathology), CNRS (French National Centre for Scientific Research), Université de Lorraine, F-54000 Nancy, France.
  • Linder M; LIBio (Laboratoire d'Ingénierie des Biomolécules), Université de Lorraine, F-54000 Nancy, France.
  • Arab-Tehrany E; LIBio (Laboratoire d'Ingénierie des Biomolécules), Université de Lorraine, F-54000 Nancy, France.
  • Bianchi A; IMoPA (Molecular Engineering and Articular Physiopathology), CNRS (French National Centre for Scientific Research), Université de Lorraine, F-54000 Nancy, France.
Int J Mol Sci ; 23(5)2022 Mar 05.
Article en En | MEDLINE | ID: mdl-35270005
The low efficiency in transfecting rat- and human-derived chondrocytes have been hampering developments in the field of cartilage biology. Transforming growth factor (TGF)-ß1 has shown positive effects on chondrocytes, but its applications remain limited due to its short half-life, low stability and poor penetration into cartilage. Naturally derived liposomes have been shown to be promising delivery nanosystems due to their similarities with biological membranes. Here, we used agro-based rapeseed liposomes, which contains a high level of mono- and poly-unsaturated fatty acids, to efficiently deliver encapsulated TGF-ß1 to rat chondrocytes. Results showed that TGF-ß1 encapsulated in nano-sized rapeseed liposomes were safe for chondrocytes and did not induce any alterations of their phenotype. Furthermore, the controlled release of TGF-ß1 from liposomes produced an improved response in chondrocytes, even at low doses. Altogether, these outcomes demonstrate that agro-based nanoliposomes are promising drug carriers.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cartílago Articular / Condrocitos Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cartílago Articular / Condrocitos Límite: Animals Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: Francia Pais de publicación: Suiza