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Association of autoimmune blistering disease, and specifically, pemphigus vulgaris, with cardiovascular disease and its risk factors: a systematic review and meta-analysis.
Rokni, Alex M; Ayasse, Marissa; Ahmed, Adnan; Guggina, Lauren; Kantor, Robert W; Silverberg, Jonathan I.
Afiliación
  • Rokni AM; The University of Illinois at Chicago, Chicago, IL, USA.
  • Ayasse M; NYU Langone Hospital - Long Island, Mineola, NY, USA.
  • Ahmed A; AMITA Health Saint Joseph Hospital Chicago, Chicago, IL, USA.
  • Guggina L; Departments of Medicine and Dermatology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
  • Kantor RW; Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, NY, USA.
  • Silverberg JI; Department of Dermatology, the George Washington University School of Medicine and Health Sciences, 2150 Pennsylvania Avenue NW Suite 2B-425, Washington, DC, 20037, USA. JonathanISilverberg@Gmail.com.
Arch Dermatol Res ; 315(2): 207-213, 2023 Mar.
Article en En | MEDLINE | ID: mdl-35262797
Previous studies have found conflicting results about the association of autoimmune blistering disease (AIBD) with cardiovascular disease (CVD) risk. The objective of the study was to systematically review the relationship of AIBD, including pemphigus vulgaris (PV), and its treatment with CVD and CVD risk factors. MEDLINE, EMBASE, Cochrane, LILACS, SCOPUS, and Web of Science were searched. We included all studies of CVD and CVD risk factors in AIBD patients. Two reviewers performed title and/or abstract review and data extraction. Pooled random-effects meta-analysis was performed. Forty papers met inclusion criteria. AIBD was associated with higher odds of diabetes (DM) (odds ratio [95% confidence interval]: 1.809 [1.258-2.601]), hypertension (HTN) (1.393 [1.088-1.784]), dyslipidemia (2.177 [1.163-4.073]) and heart failure (1.919 [1.603-2.298]), but was not associated with obesity, stroke, angina, heart attack, or arrhythmia. The pooled random-effects prevalence for treatment-related adverse events (AEs) in AIBD was 13.7% for DM, 10.7% for HTN, and 17.1% for CVD. Sensitivity analysis of high-quality studies revealed similar results. AIBD patients have increased CVD risk factors and heart failure. Systemic corticosteroid treatment results in CVD-related AEs in AIBD. Increased CVD screening and prevention strategies are warranted in AIBD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Enfermedades Cardiovasculares / Pénfigo / Insuficiencia Cardíaca / Hipertensión Tipo de estudio: Etiology_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Arch Dermatol Res Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Autoinmunes / Enfermedades Cardiovasculares / Pénfigo / Insuficiencia Cardíaca / Hipertensión Tipo de estudio: Etiology_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Arch Dermatol Res Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania