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Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists.
Gatz, Margaret; Mack, Wendy J; Chui, Helena C; Law, E Meng; Barisano, Giuseppe; Sutherland, M Linda; Sutherland, James D; Eid Rodriguez, Daniel; Quispe Gutierrez, Raul; Copajira Adrian, Juan; Bani Cuata, Jesus; Borenstein, Amy R; Walters, Ellen E; Irimia, Andrei; Rowan, Christopher J; Wann, L Samuel; Allam, Adel H; Thompson, Randall C; Miyamoto, Michael I; Michalik, David E; Cummings, Daniel K; Seabright, Edmond; Garcia, Angela R; Hooper, Paul L; Kraft, Thomas S; Finch, Caleb E; Thomas, Gregory S; Stieglitz, Jonathan; Trumble, Benjamin C; Gurven, Michael D; Kaplan, Hillard.
Afiliación
  • Gatz M; Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
  • Mack WJ; Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  • Chui HC; Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.
  • Law EM; Department of Neuroscience, Monash University, Melbourne, Victoria, Australia.
  • Barisano G; Neuroscience Graduate Program, University of Southern California, Los Angeles, California, USA.
  • Sutherland ML; MemorialCare Health Systems, Fountain Valley, California, USA.
  • Sutherland JD; MemorialCare Health Systems, Fountain Valley, California, USA.
  • Eid Rodriguez D; Institute of Biomedical Research, Faculty of Medicine, San Simon University, Cochabamba, Bolivia.
  • Quispe Gutierrez R; Tsimane Health and Life History Project, San Borja, Beni, Bolivia.
  • Copajira Adrian J; Tsimane Health and Life History Project, San Borja, Beni, Bolivia.
  • Bani Cuata J; Tsimane Health and Life History Project, San Borja, Beni, Bolivia.
  • Borenstein AR; Division of Epidemiology, Herbert Wertheim School of Public Health and Human Longevity Science, University of California San Diego School of Medicine, La Jolla, California, USA.
  • Walters EE; Center for Economic and Social Research, University of Southern California, Los Angeles, California, USA.
  • Irimia A; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
  • Rowan CJ; Corwin D. Denney Research Center, Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, California, USA.
  • Wann LS; Renown Institute for Heart and Vascular Health, Reno, Nevada, USA.
  • Allam AH; Division of Cardiology, University of New Mexico, Albuquerque, New Mexico, USA.
  • Thompson RC; Department of Cardiology, School of Medicine, Al-Azhar University, Cairo, Egypt.
  • Miyamoto MI; Saint Luke's Mid America Heart Institute, University of Missouri-Kansas City, Kansas City, Missouri, USA.
  • Michalik DE; Providence Health, Mission Viejo, California, USA.
  • Cummings DK; Memorial Care Miller Women's and Children's Hospital, Long Beach, California, USA.
  • Seabright E; Economic Science Institute, Argyos School of Business and Economics, Chapman University, Orange, California, USA.
  • Garcia AR; Department of Anthropology, University of New Mexico, Albuquerque, New Mexico, USA.
  • Hooper PL; School of Human Evolution and Social Change, and Center for Evolution and Medicine, Arizona State University, Tempe, Arizona, USA.
  • Kraft TS; Department of Anthropology, University of New Mexico, Albuquerque, New Mexico, USA.
  • Finch CE; Department of Anthropology, University of California Santa Barbara, Santa Barbara, California, USA.
  • Thomas GS; Leonard Davis School of Gerontology, University of Southern California, Los Angeles, California, USA.
  • Stieglitz J; MemorialCare Heart & Vascular Institute, Fountain Valley, California, USA.
  • Trumble BC; Division of Cardiology, University of California, Irvine, Orange, California, USA.
  • Gurven MD; Institute for Advanced Study in Toulouse, Toulouse, France.
  • Kaplan H; School of Human Evolution and Social Change, and Center for Evolution and Medicine, Arizona State University, Tempe, Arizona, USA.
Alzheimers Dement ; 19(1): 44-55, 2023 01.
Article en En | MEDLINE | ID: mdl-35262289
INTRODUCTION: We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle. METHODS: Participants from population-based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini-Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans. RESULTS: Tsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. Age-standardized MCI prevalence was 7.7% (95% CI: 5.2, 10.3) in Tsimane and 9.8% (95% CI: 4.9, 14.6) in Moseten. Cognitive impairment was associated with visuospatial impairments, parkinsonian symptoms, and vascular calcification in the basal ganglia. DISCUSSION: The prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non-Alzheimer's disease (AD) dementia phenotype.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Demencia / Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Humans País/Región como asunto: America do sul / Bolivia Idioma: En Revista: Alzheimers Dement Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Demencia / Enfermedad de Alzheimer / Disfunción Cognitiva Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Humans País/Región como asunto: America do sul / Bolivia Idioma: En Revista: Alzheimers Dement Año: 2023 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos