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Clinical Feasibility of Shear Wave Dispersion Slope for Noninvasive Diagnosis of Nonalcoholic Steatohepatitis in Patients With Morbid Obesity: Preliminary Results Using US Shear Wave Elastography.
Kim, Yeonsoo; Hwang, Jiyoung; Bae, Sung Hwan; Hong, Seong Sook; Chang, Yun-Woo; Kim, Hyun-Joo; Kim, Sang Hyun; Jin, So-Young.
Afiliación
  • Kim Y; Department of Radiology, Soonchunhyang University College of Medicine, Seoul Hospital.
  • Hwang J; Department of Radiology, Soonchunhyang University College of Medicine, Seoul Hospital.
  • Bae SH; Department of Radiology, Soonchunhyang University College of Medicine, Seoul Hospital.
  • Hong SS; Department of Radiology, Soonchunhyang University College of Medicine, Seoul Hospital.
  • Chang YW; Department of Radiology, Soonchunhyang University College of Medicine, Seoul Hospital.
  • Kim HJ; Department of Radiology, Soonchunhyang University College of Medicine, Seoul Hospital.
  • Kim SH; Department of Surgery, Soonchunhyang University College of Medicine, Seoul Hospital.
  • Jin SY; Department of Pathology, Soonchunhyang University College of Medicine, Seoul Hospital, Seoul, Republic of Korea.
Ultrasound Q ; 38(2): 149-154, 2022 Jun 01.
Article en En | MEDLINE | ID: mdl-35250014
ABSTRACT: We aimed to investigate the clinical feasibility of shear wave dispersion slope for assessing nonalcoholic steatohepatitis (NASH) in patients with morbid obesity before bariatric surgery.This prospective study collected data from 25 participants who received liver biopsy during bariatric surgery between February 2019 and December 2020. All participants underwent ultrasonography shear wave elastography before surgery and shear wave speed and shear wave dispersion slope were measured. Liver specimens were evaluated by 1 pathologist scored histologically for nonalcoholic fatty liver disease (NAFLD). Ultrasonography measurements were compared according to histopathologic findings. Diagnostic performance in differentiating NASH from NAFLD was evaluated using the area under the receiver operating characteristic curve (AUC). Median shear wave speed (1.48 vs 1.62 m/s, P = 0.014) and dispersion slope (8.40 vs 11.80 [m/s]/kHz, P = 0.004) were higher in NASH group than in NAFLD group. Shear wave dispersion slope tended to increase step by step as the severity of activity grade (P = 0.032) and hepatic fibrosis (P = 0.015) increased. The AUC of shear wave dispersion slope for differentiating NASH from NAFLD (AUC, 0.83; 95% confidence intervals, 0.66-1.00) was higher than that of shear wave speed (AUC, 0.78; 95% CI, 0.60-0.97), although it did not reach statistical significance (P = 0.729). Shear wave dispersion slope could be a feasible tool for assessing NASH in patients with morbid obesity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Diagnóstico por Imagen de Elasticidad / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Ultrasound Q Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Mórbida / Diagnóstico por Imagen de Elasticidad / Enfermedad del Hígado Graso no Alcohólico Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Ultrasound Q Asunto de la revista: DIAGNOSTICO POR IMAGEM Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos