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Fungemia due to Moesziomyces aphidis (Pseudozyma aphidis) in a premature neonate. Challenges in species identification and antifungal susceptibility testing of rare yeasts.
Mpakosi, Alexandra; Siopi, Maria; Demetriou, Maria; Falaina, Vasiliki; Theodoraki, Martha; Meletiadis, Joseph.
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  • Mpakosi A; Department of Microbiology, General Hospital of Nikaia Agios Panteleimon, Athens, Greece.
  • Siopi M; Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Demetriou M; Department of Microbiology, Metaxa Memorial Anticancer Hospital of Piraeus, Greece.
  • Falaina V; Neonatal Intensive Care Unit, General Hospital of Nikaia Agios Panteleimon, Athens, Greece.
  • Theodoraki M; Neonatal Intensive Care Unit, General Hospital of Nikaia Agios Panteleimon, Athens, Greece.
  • Meletiadis J; Clinical Microbiology Laboratory, Attikon University Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece. Electronic address: jmeletiadis@med.uoa.gr.
J Mycol Med ; 32(3): 101258, 2022 Aug.
Article en En | MEDLINE | ID: mdl-35247802
Premature neonates are at particularly increased risk to develop invasive infections with excessive case fatality due to their low birth weight, enteral malabsorbtion, insufficient microbial defenses and underdeveloped anatomic barriers. We present a case of Moesziomyces aphidis (syn. Pseudozyma aphidis) fungemia in a newborn with severe morbidity and prolonged hospital stay. Phenotypic tests failed to identify the isolate whereas commercial antifungal susceptibility tests failed to detect resistance to fluconazole. To the best of our knowledge, this is the first case of M. aphidis fungemia in a premature neonate in whom complete clinical resolution occurred after liposomal amphotericin B administration. Our case is the third Pseudozyma spp. infection described in Europe. Twenty-one cases have been described globally. Common risk factors were central venus catheter (80%), previous antibiotic treatment (80%), hematologic malignancies (27%) and solid tumors (20%) with 3 cases reported in neonates. The most commonly used antifungal therapy was amphotericin B followed by oral voriconazole or itraconazole. Our report highlights the clinical importance of rare yeasts species in neonates, emphasizes the roles of prematurity and lower birth weight as major risk factors for invasive infections with high morbidity. Reliable identification and susceptibility testing of these rare yeasts is a key issue for an adequate therapy and better outcome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Basidiomycota / Fungemia / Enfermedades del Recién Nacido Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Newborn Idioma: En Revista: J Mycol Med Año: 2022 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Basidiomycota / Fungemia / Enfermedades del Recién Nacido Tipo de estudio: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Límite: Humans / Newborn Idioma: En Revista: J Mycol Med Año: 2022 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Francia