Small-volume <i>in vitro</i> lipid digestion measurements for assessing drug dissolution in lipid-based formulations using SAXS.

Khan, Nafia F; Salim, Malinda; Binte Abu Bakar, Syaza Y; Ristroph, Kurt; Prud'homme, Robert K; Hawley, Adrian; Boyd, Ben J; Clulow, Andrew J

Small-volume in vitro lipid digestion measurements for assessing drug dissolution in lipid-based formulations using SAXS.

Khan, Nafia F; Salim, Malinda; Binte Abu Bakar, Syaza Y; Ristroph, Kurt; Prud'homme, Robert K; Hawley, Adrian; Boyd, Ben J; Clulow, Andrew J.

Afiliación

Khan NF; UCL School of Pharmacy, University College London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Salim M; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.
Binte Abu Bakar SY; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.
Ristroph K; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.
Prud'homme RK; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, United States.
Hawley A; Department of Chemical and Biological Engineering, Princeton University, Princeton, NJ 08544, United States.
Boyd BJ; Australian Synchrotron, ANSTO, 800 Blackburn Road, Clayton, Victoria 3168, Australia.
Clulow AJ; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia.

Int J Pharm X ; 4: 100113, 2022 Dec.

Article en En | MEDLINE | ID: mdl-35243327

Palabras clave

3DP, 3D-printed; API, active pharmaceutical ingredient; CFZ, clofazimine; CIJ, confined impinging jet; DLS, dynamic light scattering; EE, encapsulation efficiency; F X, polymorphic form X; FA, fatty acid; FFA, free fatty acid; FNP, Flash NanoPrecipitation; Hf, halofantrine; IF, infant formula; Infant formula; LBFs, lipid-based formulations; LC, loading capacity; Lipid digestion; Lipid-based formulations; PDI, polydispersity index; PLA, polylactic acid; SAXS, small-angle X-ray scattering; Small angle X-ray scattering; THF, tetrahydrofuran; XRD, X-ray diffraction; iFast, simulated infant fasted intestinal media

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Int J Pharm X Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Países Bajos

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