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Nanoprobes for Computed Tomography and Magnetic Resonance Imaging in Atherosclerosis Research.
Ghaghada, Ketan B; Bhavane, Rohan; Badachhape, Andrew; Tanifum, Eric; Annapragada, Ananth.
Afiliación
  • Ghaghada KB; E.B. Singleton Department of Radiology, Texas Children's Hospital & Baylor College of Medicine, Houston, TX, USA.
  • Bhavane R; E.B. Singleton Department of Radiology, Texas Children's Hospital & Baylor College of Medicine, Houston, TX, USA.
  • Badachhape A; E.B. Singleton Department of Radiology, Texas Children's Hospital & Baylor College of Medicine, Houston, TX, USA.
  • Tanifum E; E.B. Singleton Department of Radiology, Texas Children's Hospital & Baylor College of Medicine, Houston, TX, USA.
  • Annapragada A; E.B. Singleton Department of Radiology, Texas Children's Hospital & Baylor College of Medicine, Houston, TX, USA. annaprag@bcm.edu.
Methods Mol Biol ; 2419: 809-823, 2022.
Article en En | MEDLINE | ID: mdl-35238003
Atheromatous lesions are characterized by intrusion into the vascular lumen, resulting in morphological changes to the blood compartment and into the vessel wall, resulting in characteristic molecular and cellular signatures in the solid tissue of the intima, tunica media, adventitia and surrounding tissue. Nanoprobes can be easily formulated to provide long blood-pool residence and molecular targeting, facilitating the imaging of atheromatous changes. Detection of nanoprobes can be accomplished by a variety of methods. We focus in this chapter on the use of cross-sectional imaging techniques, computed tomography (CT) and magnetic resonance imaging (MRI), that facilitate in vivo, noninvasive imaging of the vascular morphology and molecular/cellular signatures of the atheroma. The methods described are suitable for use in animal models, although versions of the probes are being readied for clinical trials, potentially facilitating clinical use in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aterosclerosis / Placa Aterosclerótica Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aterosclerosis / Placa Aterosclerótica Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Methods Mol Biol Asunto de la revista: BIOLOGIA MOLECULAR Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos