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Managing Cachexia in Head and Neck Cancer: a Systematic Scoping Review.
Mäkitie, Antti A; Alabi, Rasheed Omobolaji; Orell, Helena; Youssef, Omar; Almangush, Alhadi; Homma, Akihiro; Takes, Robert P; López, Fernando; de Bree, Remco; Rodrigo, Juan P; Ferlito, Alfio.
Afiliación
  • Mäkitie AA; Department of Otorhinolaryngology-Head and Neck Surgery, University of Helsinki and Helsinki University Hospital, P.O. Box 263, 00029 HUS, Helsinki, Finland. antti.makitie@helsinki.fi.
  • Alabi RO; Faculty of Medicine, Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland. antti.makitie@helsinki.fi.
  • Orell H; Division of Ear, Nose and Throat Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden. antti.makitie@helsinki.fi.
  • Youssef O; Faculty of Medicine, Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland.
  • Almangush A; Department of Industrial Digitalization, School of Technology and Innovations, University of Vaasa, Vaasa, Finland.
  • Homma A; Clinical Nutrition Unit, Internal Medicine and Rehabilitation, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
  • Takes RP; Faculty of Medicine, Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland.
  • López F; Department of Pathology, University of Helsinki, Helsinki, Finland.
  • de Bree R; Faculty of Medicine, Research Program in Systems Oncology, University of Helsinki, Helsinki, Finland.
  • Rodrigo JP; Department of Pathology, University of Helsinki, Helsinki, Finland.
  • Ferlito A; Institute of Biomedicine, Pathology, University of Turku, Turku, Finland.
Adv Ther ; 39(4): 1502-1523, 2022 04.
Article en En | MEDLINE | ID: mdl-35224702
INTRODUCTION: Patients with head and neck cancer (HNC) are usually confronted with functional changes due to the malignancy itself or its treatment. These factors typically affect important structures involved in speech, breathing, chewing, swallowing, and saliva production. Consequently, the intake of food will be limited, which further contributes to loss of body weight and muscle mass, anorexia, malnutrition, fatigue, and anemia. This multifactorial condition can ultimately lead to cancer cachexia syndrome. This study aims to examine the treatment of cachexia in HNC patients. METHODS: We systematically searched OvidMedline, PubMed, Scopus, and Web of Science for articles examining the treatment of cachexia in HNC. RESULTS: A total of nine studies were found, and these suggested interventions including nutritional, pharmacologic, therapeutic exercise, and multimodal approaches. The nutritional intervention includes essential components such as dietary counseling, oral nutritional supplements, and medical nutritional support. Individualized nutritional interventions include oral, enteral (feeding tubes i.e., percutaneous endoscopic gastrostomy [PEG], nasogastric tube [NGT]) and parenteral nutrition. The pharmacologic interventions aim at increasing the appetite and weight of cachectic patients. Therapeutic exercise and increased physical activity can help to enhance the synthesis of muscle protein, reducing inflammation and the catabolic effects of cachexia syndrome. CONCLUSION: Owing to the multifactorial nature of this syndrome, it is expected that the management approach should be multi-interventional. Early implementation of these interventions may help to improve survival and quality of health and life of cachectic HNC patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desnutrición / Neoplasias de Cabeza y Cuello Tipo de estudio: Etiology_studies / Systematic_reviews Aspecto: Determinantes_sociais_saude Límite: Humans Idioma: En Revista: Adv Ther Asunto de la revista: TERAPEUTICA Año: 2022 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Desnutrición / Neoplasias de Cabeza y Cuello Tipo de estudio: Etiology_studies / Systematic_reviews Aspecto: Determinantes_sociais_saude Límite: Humans Idioma: En Revista: Adv Ther Asunto de la revista: TERAPEUTICA Año: 2022 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos