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Vaccine building 'kit': combining peptide bricks to elicit a desired immune response without adding an adjuvant.
Gorbunov, Aleksandr A; Sannikova, Evgeniia P; Gubaidullin, Irek I; Serobyan, Gayane A; Gorbunova, Alina Yu; Serkina, Anna V; Plokhikh, Konstantin S; Kamyshinsky, Roman A; Vorovitch, Mikhail F; Bulushova, Natalia V; Kuchin, Sergei; Kozlov, Dmitry G.
Afiliación
  • Gorbunov AA; National Research Center 'Kurchatov Institute', Moscow, 123182, Russia.
  • Sannikova EP; National Research Center 'Kurchatov Institute', Moscow, 123182, Russia.
  • Gubaidullin II; National Research Center 'Kurchatov Institute', Moscow, 123182, Russia.
  • Serobyan GA; National Research Center 'Kurchatov Institute' - GOSNIIGENETIKA, Kurchatov Genomic Center, Moscow, 117545, Russia.
  • Gorbunova AY; National Research Center 'Kurchatov Institute', Moscow, 123182, Russia.
  • Serkina AV; National Research Center 'Kurchatov Institute', Moscow, 123182, Russia.
  • Plokhikh KS; National Research Center 'Kurchatov Institute', Moscow, 123182, Russia.
  • Kamyshinsky RA; National Research Center 'Kurchatov Institute', Moscow, 123182, Russia.
  • Vorovitch MF; National Research Center 'Kurchatov Institute', Moscow, 123182, Russia.
  • Bulushova NV; FSBSI 'Chumakov FSC R&D IBP RAS', Moscow, 108819, Russia.
  • Kuchin S; Institute of Translational Medicine & Biotechnology, Sechenov First Moscow State Medical University, Moscow, 119991, Russia.
  • Kozlov DG; National Research Center 'Kurchatov Institute', Moscow, 123182, Russia.
Nanomedicine (Lond) ; 17(7): 461-475, 2022 03.
Article en En | MEDLINE | ID: mdl-35220724
We aimed to extend the arsenal of protein platforms used for vaccine development. To this end, in this proof-of-concept study we constructed new self-assembling fusion proteins consisting of three modules. Module 1 is responsible for the self-assembly, while modules 2 and 3 are responsible for the immune response. Modules 1 and 2 form the platform, while module 3 represents the target antigen exposed on the surface of the self-assembled nanoparticles. After conventional biosynthesis in Escherichia coli, the proteins undergo efficient self-assembly during purification, and the resulting nanoparticles elicit a strong immune response without using an enhancing agent (adjuvant). The simple modular design and a high target-to-platform ratio of the immune response make our system a promising approach for practical applications, including vaccine development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / Nanopartículas Límite: Animals Idioma: En Revista: Nanomedicine (Lond) Año: 2022 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vacunas / Nanopartículas Límite: Animals Idioma: En Revista: Nanomedicine (Lond) Año: 2022 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Reino Unido