Design, synthesis, and biological evaluation of novel spiro[pyrrolidine-2,3'-quinolin]-2'-one derivatives as potential chitin synthase inhibitors and antifungal agents.

Wu, Hu; Du, Chuanbiao; Xu, Yajie; Liu, Lige; Zhou, Xin; Ji, Qinggang

Wu, Hu; Du, Chuanbiao; Xu, Yajie; Liu, Lige; Zhou, Xin; Ji, Qinggang.

Afiliación

Wu H; School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.
Du C; School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.
Xu Y; School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.
Liu L; School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.
Zhou X; School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China.
Ji Q; School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China. Electronic address: jiqing@swu.edu.cn.

Eur J Med Chem ; 233: 114208, 2022 Apr 05.

Article en En | MEDLINE | ID: mdl-35220015

Asunto(s)

Antifúngicos; Quitina Sintasa; Antifúngicos/química; Candida albicans; Quitina/farmacología; Diseño de Fármacos; Inhibidores Enzimáticos/química; Pruebas de Sensibilidad Microbiana; Pirrolidinas/farmacología; Relación Estructura-Actividad

Palabras clave

Antimycotic; Drug combination; Drug-resistant fungi; Spiro-quinolinone

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quitina Sintasa / Antifúngicos Idioma: En Revista: Eur J Med Chem Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Francia

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