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Electrolyte profiles with induced hypothermia: A sub study of a clinical trial evaluating the duration of hypothermia after cardiac arrest.
Kirkegaard, Hans; Grejs, Anders M; Gudbjerg, Simon; Duez, Christophe; Jeppesen, Anni; Hassager, Christian; Laitio, Timo; Storm, Christian; Taccone, Fabio Silvio; Skrifvars, Markus B; Søreide, Eldar.
Afiliación
  • Kirkegaard H; Research Center for Emergency Medicine, Emergency Department, Aarhus University Hospital, Aarhus, Denmark.
  • Grejs AM; Research Center for Emergency Medicine, Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Gudbjerg S; Department of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.
  • Duez C; Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
  • Jeppesen A; Department of Anaesthesia and Intensive Care, Aalborg University Hospital, Aalborg, Denmark.
  • Hassager C; Department of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.
  • Laitio T; Department of Intensive Care, Aarhus University Hospital, Aarhus, Denmark.
  • Storm C; Department of Cardiology, Rigshospitalet, Copenhagen, Denmark.
  • Taccone FS; Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
  • Skrifvars MB; Division of Perioperative Services, Intensive Care Medicine and Pain Management, Turku University Hospital, University of Turku, Finland.
  • Søreide E; Department of Internal Medicine, Nephrology and Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Acta Anaesthesiol Scand ; 66(5): 615-624, 2022 05.
Article en En | MEDLINE | ID: mdl-35218019
BACKGROUND: Electrolyte disturbances can result from targeted temperature treatment (TTM) in out-of-hospital cardiac arrest (OHCA) patients. This study explores electrolyte changes in blood and urine in OHCA patients treated with TTM. METHODS: This is a sub-study of the TTH48 trial, with the inclusion of 310 unconscious OHCA patients treated with TTM at 33°C for 24 or 48 h. Over a three-day period, serum concentrations were obtained on sodium potassium, chloride, ionized calcium, magnesium and phosphate, as were results from a 24-h diuresis and urine electrolyte concentration and excretion. Changes over time were analysed with a mixed-model multivariate analysis of variance with repeated measurements. RESULTS: On admission, mean ± SD sodium concentration was 138 ± 3.5 mmol/l, which increased slightly but significantly (p < .05) during the first 24 h. Magnesium concentration stayed within the reference interval. Median ionized calcium concentration increased from 1.11 (IQR 1.1-1.2) mmol/l during the first 24 h (p < .05), whereas median phosphate concentration dropped to 1.02 (IQR 0.8-1.2) mmol/l (p < .05) and stayed low. During rewarming, potassium concentrations increased, and magnesium and ionizes calcium concentration decreased (p < .05). Median 24-h diuresis results on days one and two were 2198 and 2048 ml respectively, and the electrolyte excretion mostly stayed low in the reference interval. CONCLUSIONS: Electrolytes mostly remained within the reference interval. A temporal change occurred in potassium, magnesium and calcium concentrations with TTM's different phases. No hypothermia effect on diuresis was detected, and urine excretion of electrolytes mostly stayed low.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Paro Cardíaco Extrahospitalario / Hipotermia / Hipotermia Inducida Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Acta Anaesthesiol Scand Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Paro Cardíaco Extrahospitalario / Hipotermia / Hipotermia Inducida Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Acta Anaesthesiol Scand Año: 2022 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Reino Unido