Possible physiological functions of penicillin-binding proteins in Staphylococcus aureus.
Antimicrob Agents Chemother
; 29(2): 333-6, 1986 Feb.
Article
en En
| MEDLINE
| ID: mdl-3521479
There are four penicillin-binding proteins (PBPs) in Staphylococcus aureus, of which PBPs 2 and 3 are essential. Cefotaxime binds selectively to PBP 2, and cephalexin binds to PBP 3, each at its respective MIC. The morphology of S. aureus strains grown in the presence of the two antibiotics was examined by phase-contrast and scanning electron microscopy. Exposure of the cells to cefotaxime at concentrations at which it bound selectively to PBP 2 resulted in the extrusion of cytoplasm and cell lysis, whereas exposure to cephalexin at concentrations at which it bound exclusively to PBP 3 resulted in cell enlargement and the cessation of septation. The latter morphological response was very similar to that produced by norfloxacin. The results suggest that in S. aureus, PBP 2 may be the primary peptidoglycan transpeptidase, and PBP 3 may be involved in septation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Staphylococcus aureus
/
Proteínas Bacterianas
/
Aciltransferasas
/
Muramoilpentapéptido Carboxipeptidasa
/
Carboxipeptidasas
/
Proteínas Portadoras
/
Peptidil Transferasas
/
Aminoaciltransferasas
/
Hexosiltransferasas
Idioma:
En
Revista:
Antimicrob Agents Chemother
Año:
1986
Tipo del documento:
Article
Pais de publicación:
Estados Unidos