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Protein expression of transmembrane protease serine 4 in the gastrointestinal tract and in healthy, cancer, and SARS­CoV­2 infected lungs.
Kerslake, Rachel; Randeva, Harpal S; Jonigk, Danny; Werlein, Christopher; Robertus, Jan L; Katopodis, Periklis; Jasker, Petra; Spandidos, Demetrios A; Kyrou, Ioannis; Karteris, Emmanouil.
Afiliación
  • Kerslake R; Division of Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH.
  • Randeva HS; Warwickshire Institute for The Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire (UHCW) NHS Trust, Coventry CV2 2DX, UK.
  • Jonigk D; Institute for Pathology, Hannover Medical School, D­30625 Hannover, Germany.
  • Werlein C; Institute for Pathology, Hannover Medical School, D­30625 Hannover, Germany.
  • Robertus JL; National Heart and Lung Institute, Imperial College London, London SW3 6LY, UK.
  • Katopodis P; Division of Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.
  • Jasker P; Pathologie Grünstrasse, D­40212 Düsseldorf, Germany.
  • Spandidos DA; Laboratory of Clinical Virology, Medical School, University of Crete, 71409 Heraklion, Greece.
  • Kyrou I; Warwickshire Institute for The Study of Diabetes, Endocrinology and Metabolism (WISDEM), University Hospitals Coventry and Warwickshire (UHCW) NHS Trust, Coventry CV2 2DX, UK.
  • Karteris E; Division of Biosciences, College of Health, Medicine and Life Sciences, Brunel University London, Uxbridge UB8 3PH, UK.
Mol Med Rep ; 25(4)2022 04.
Article en En | MEDLINE | ID: mdl-35211765
In addition to the angiotensin­converting enzyme 2 (ACE2), a number of host cell entry mediators have been identified for severe acute respiratory syndrome coronavirus­2 (SARS­CoV­2), including transmembrane protease serine 4 (TMPRSS4). The authors have recently demonstrated the upregulation of TMPRSS4 in 11 different cancers, as well as its specific expression within the central nervous system using in silico tools. The present study aimed to expand the initial observations and, using immunohistochemistry, TMPRSS4 protein expression in the gastrointestinal (GI) tract and lungs was further mapped. Immunohistochemistry was performed on tissue arrays and lung tissues of patients with non­small cell lung cancer with concurrent coronavirus disease 2019 (COVID­19) infection using TMPRSS4 antibody. The results revealed that TMPRSS4 was abundantly expressed in the oesophagus, stomach, small intestine, jejunum, ileum, colon, liver and pancreas. Moreover, the extensive TMPRSS4 protein expression in the lungs of a deceased patient with COVID­19 with chronic obstructive pulmonary disease and bronchial carcinoma, as well in the adjacent normal tissue, was demonstrated for the first time, at least to the best of our knowledge. On the whole, the immunohistochemistry data of the present study suggest that TMPRSS4 may be implicated in the broader (pulmonary and extra­pulmonary) COVID­19 symptomatology; thus, it may be responsible for the tropism of this coronavirus both in the GI tract and lungs.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serina Endopeptidasas / Tracto Gastrointestinal / COVID-19 / Pulmón / Neoplasias Pulmonares / Proteínas de la Membrana Tipo de estudio: Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: Mol Med Rep Año: 2022 Tipo del documento: Article Pais de publicación: Grecia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Serina Endopeptidasas / Tracto Gastrointestinal / COVID-19 / Pulmón / Neoplasias Pulmonares / Proteínas de la Membrana Tipo de estudio: Prognostic_studies Límite: Aged / Humans / Male Idioma: En Revista: Mol Med Rep Año: 2022 Tipo del documento: Article Pais de publicación: Grecia