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Circular RNAs Modulate Cancer Hallmark and Molecular Pathways to Support Cancer Progression and Metastasis.
Yarmishyn, Aliaksandr A; Ishola, Afeez Adekunle; Chen, Chieh-Yu; Verusingam, Nalini Devi; Rengganaten, Vimalan; Mustapha, Habeebat Aderonke; Chuang, Hao-Kai; Teng, Yuan-Chi; Phung, Van Long; Hsu, Po-Kuei; Lin, Wen-Chang; Ma, Hsin-I; Chiou, Shih-Hwa; Wang, Mong-Lien.
Afiliación
  • Yarmishyn AA; Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan.
  • Ishola AA; Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan.
  • Chen CY; Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei 112, Taiwan.
  • Verusingam ND; Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan.
  • Rengganaten V; Taiwan International Graduate Program in Molecular Medicine, National Yang Ming Chiao Tung University and Academia Sinica, Taipei 112, Taiwan.
  • Mustapha HA; Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan.
  • Chuang HK; Institute of Pharmacology, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
  • Teng YC; Centre for Stem Cell Research, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Kajang 43000, Malaysia.
  • Phung VL; Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan.
  • Hsu PK; Institute of Pharmacology, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
  • Lin WC; Postgraduate Programme, Department of Preclinical Sciences, Faculty of Medicine and Health Sciences, Universiti Tunku Abdul Rahman, Kajang 43000, Malaysia.
  • Ma HI; Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan.
  • Chiou SH; Institute of Pharmacology, School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
  • Wang ML; Department of Medical Research, Taipei Veterans General Hospital, Taipei 112, Taiwan.
Cancers (Basel) ; 14(4)2022 Feb 09.
Article en En | MEDLINE | ID: mdl-35205610
Circular RNAs (circRNAs) are noncoding products of backsplicing of pre-mRNAs which have been established to possess potent biological functions. Dysregulated circRNA expression has been linked to diseases including different types of cancer. Cancer progression is known to result from the dysregulation of several molecular mechanisms responsible for the maintenance of cellular and tissue homeostasis. The dysregulation of these processes is defined as cancer hallmarks, and the molecular pathways implicated in them are regarded as the targets of therapeutic interference. In this review, we summarize the literature on the investigation of circRNAs implicated in cancer hallmark molecular signaling. First, we present general information on the properties of circRNAs, such as their biogenesis and degradation mechanisms, as well as their basic molecular functions. Subsequently, we summarize the roles of circRNAs in the framework of each cancer hallmark and finally discuss the potential as therapeutic targets.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Cancers (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza