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IL-6, IL-1RA and Resistin as Predictors of Left Ventricular Remodelling and Major Adverse Cardiac Events in Patients with Acute ST Elevation Myocardial Infarction.
Scarlatescu, Alina Ioana; Micheu, Miruna Mihaela; Popa-Fotea, Nicoleta; Pascal, Ana Maria; Mihail, Ana Maria; Petre, Ioana; Deaconu, Silvia; Vîjîiac, Aura; Dorobanțu, Maria.
Afiliación
  • Scarlatescu AI; Department of Cardiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Micheu MM; Emergency Clinical Hospital Bucharest, Department of Cardiology, 014461 Bucharest, Romania.
  • Popa-Fotea N; Emergency Clinical Hospital Bucharest, Department of Cardiology, 014461 Bucharest, Romania.
  • Pascal AM; Department of Cardiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Mihail AM; Emergency Clinical Hospital Bucharest, Department of Cardiology, 014461 Bucharest, Romania.
  • Petre I; Emergency Clinical Hospital Bucharest, Department of Cardiology, 014461 Bucharest, Romania.
  • Deaconu S; Emergency Clinical Hospital Bucharest, Department of Cardiology, 014461 Bucharest, Romania.
  • Vîjîiac A; Department of Cardiology, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
  • Dorobanțu M; Emergency Clinical Hospital Bucharest, Department of Cardiology, 014461 Bucharest, Romania.
Diagnostics (Basel) ; 12(2)2022 Jan 21.
Article en En | MEDLINE | ID: mdl-35204357
Despite continuous advances in diagnostic and therapeutic methods, acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. Considering the role of inflammation in AMI etiopathogenesis, we aimed to explore the role of a group of three inflammatory cytokines (IL-1RA, IL-6 and resistin) as an independent prognostic factor for LVR assessed by 3D echocardiography and MACE in patients with STEMI. We enrolled 41 patients with STEMI who underwent primary PCI. We assessed the occurrence of LVR (defined as an increase of over 20% in end-diastolic left ventricular volume at 6 months compared with baseline values) and MACE. Using the enzyme-linked immunosorbent assays (ELISA) method, we measured plasmatic levels of IL-6, IL-1RA and resistin (within 48 h after AMI and at 6 months). Out of 41 STEMI patients, 20.5% presented signs of LVR at follow up, and in 24.4%, MACE occurred. In univariate logistic regression analysis, baseline levels of IL-6 (OR = 1.042, p = 0.004), IL-1RA (OR = 1.004, p = 0.05) and resistin (OR = 1.7, p = 0.007) were all significantly associated with LVR. ROC analysis showed that the three cytokines as a group (AUC 0.946, p = 0.000) have a better predictive value for LVR than any individual cytokine. The group of cytokines also proved to have a better predictive value for MACE together than separately (AUC = 0.875, p = 0.000 for ROC regression model). IL-6, IL-1RA and resistin plasma levels at baseline have a good predictive value both as independent variables and also as a group for the development of adverse LVR and MACE at 6 months follow up after STEMI.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Diagnostics (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Diagnostics (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza