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Incidence and Risk Factors for Acute Kidney Injury after Allogeneic Stem Cell Transplantation: A Prospective Study.
Andronesi, Andreea; Sorohan, Bogdan; Burcea, Andreea; Lipan, Lavinia; Stanescu, Cristina; Craciun, Oana; Stefan, Laura; Ranete, Adela; Varady, Zsofia; Ungureanu, Oana; Lupusoru, Gabriela; Agrigoroaei, Gabriela; Andronesi, Danut; Iliuta, Luminita; Obrisca, Bogdan; Tanase, Alina.
Afiliación
  • Andronesi A; Department of Nephrology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Sorohan B; Nephrology Department, Fundeni Clinical Institute, 022328 Bucharest, Romania.
  • Burcea A; Department of Nephrology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Lipan L; Nephrology Department, Fundeni Clinical Institute, 022328 Bucharest, Romania.
  • Stanescu C; Nephrology Department, Fundeni Clinical Institute, 022328 Bucharest, Romania.
  • Craciun O; Bone Marrow Transplant Department, Fundeni Clinical Institute, 022328 Bucharest, Romania.
  • Stefan L; Nephrology Department, Fundeni Clinical Institute, 022328 Bucharest, Romania.
  • Ranete A; Bone Marrow Transplant Department, Fundeni Clinical Institute, 022328 Bucharest, Romania.
  • Varady Z; Bone Marrow Transplant Department, Fundeni Clinical Institute, 022328 Bucharest, Romania.
  • Ungureanu O; Bone Marrow Transplant Department, Fundeni Clinical Institute, 022328 Bucharest, Romania.
  • Lupusoru G; Bone Marrow Transplant Department, Fundeni Clinical Institute, 022328 Bucharest, Romania.
  • Agrigoroaei G; Nephrology Department, Fundeni Clinical Institute, 022328 Bucharest, Romania.
  • Andronesi D; Department of Nephrology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Iliuta L; Nephrology Department, Fundeni Clinical Institute, 022328 Bucharest, Romania.
  • Obrisca B; Department of Nephrology, Carol Davila University of Medicine and Pharmacy, 020021 Bucharest, Romania.
  • Tanase A; Department of General Surgery and Liver Transplant, Fundeni Clinical Institute, 022328 Bucharest, Romania.
Biomedicines ; 10(2)2022 Jan 25.
Article en En | MEDLINE | ID: mdl-35203472
(1) Background: Acute kidney injury (AKI) is a serious complication of hematopoietic stem cell transplantation (HSCT). (2) Methods: The aim was to identify the incidence, severity, and risk factors for AKI during the first 100 days after allo-HSCT; we performed a prospective observational study on 135 consecutive patients. (3) Results: The mean age was 38.3 ± 11.9 years (50.6% females), AKI developed in 93 patients (68.9%), the median time of appearance was 28 days, and the mean serum creatinine at the time of AKI was 1.8 ± 0.8 mg/dL. A total of 36 (38.7%) patients developed stage 1 AKI, 33 (35.5%) patients developed stage 2, and 24 (25.8%) patients developed stage 3; eight (8.6%) patients required temporary hemodialysis, and the mortality rate in these patients was 87.5%. Death was twice as frequent in the AKI subgroup, without statistical significance. Cyclosporine overdose (HR = 2.36, 95% CI: 1.45-3.85, p = 0.001), tacrolimus overdose (HR = 4.72, 95% CI: 2.22-10.01, p < 0.001), acute graft-versus-host disease (aGVHD) (HR = 1.96, 95% CI: 1.13-3.40, p = 0.01), and CRP level (HR = 1.009, 95% CI: 1.007-1.10, p < 0.001) were independent risk factors for AKI. Sepsis (HR = 5.37, 95% CI: 1.75-16.48, p = 0.003) and sinusoidal obstruction syndrome (HR = 5.10, 95% CI: 2.02-12.85, p = 0.001) were found as independent risk factors for AKI stage 3. (4) Conclusions: AKI occurs with high incidence and increased severity after allo-HSCT. Careful monitoring of calcineurin inhibitors and proper management of sepsis may reduce this risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Biomedicines Año: 2022 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Idioma: En Revista: Biomedicines Año: 2022 Tipo del documento: Article País de afiliación: Rumanía Pais de publicación: Suiza