ACAGT-007a, an ERK MAPK Signaling Modulator, in Combination with AKT Signaling Inhibition Induces Apoptosis in KRAS Mutant Pancreatic Cancer T3M4 and MIA-Pa-Ca-2 Cells.

Khandakar, Golam Iftakhar; Satoh, Ryosuke; Takasaki, Teruaki; Fujitani, Kana; Tanabe, Genzoh; Sakai, Kazuko; Nishio, Kazuto; Sugiura, Reiko

Khandakar, Golam Iftakhar; Satoh, Ryosuke; Takasaki, Teruaki; Fujitani, Kana; Tanabe, Genzoh; Sakai, Kazuko; Nishio, Kazuto; Sugiura, Reiko.

Afiliación

Khandakar GI; Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University, Osaka 577-8502, Japan.
Satoh R; Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University, Osaka 577-8502, Japan.
Takasaki T; Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University, Osaka 577-8502, Japan.
Fujitani K; Laboratory of Molecular Pharmacogenomics, Department of Pharmaceutical Sciences, Faculty of Pharmacy, Kindai University, Osaka 577-8502, Japan.
Tanabe G; Laboratory of Organic Chemistry, Department of Pharmacy, Faculty of Pharmacy, Kindai University, Osaka 577-8502, Japan.
Sakai K; Department of Genome Biology, Kindai University School of Medicine, Osaka 589-8511, Japan.
Nishio K; Department of Genome Biology, Kindai University School of Medicine, Osaka 589-8511, Japan.
Sugiura R; Laboratory of Organic Chemistry, Department of Pharmacy, Faculty of Pharmacy, Kindai University, Osaka 577-8502, Japan.

Cells ; 11(4)2022 02 17.

Article en En | MEDLINE | ID: mdl-35203351

Asunto(s)

Carcinoma Ductal Pancreático; Neoplasias Pancreáticas; Apoptosis; Carcinoma Ductal Pancreático/tratamiento farmacológico; Carcinoma Ductal Pancreático/genética; Línea Celular Tumoral; Humanos; Proteínas Quinasas Activadas por Mitógenos/metabolismo; Neoplasias Pancreáticas/tratamiento farmacológico; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/metabolismo; Fosfatidilinositol 3-Quinasa/metabolismo; Fosfatidilinositol 3-Quinasas/metabolismo; Proteínas Proto-Oncogénicas c-akt/metabolismo; Proteínas Proto-Oncogénicas p21(ras)/genética; Proteínas Proto-Oncogénicas p21(ras)/metabolismo; Neoplasias Pancreáticas

Palabras clave

ACAGT-007a (GT-7); AKT signaling; ERK MAPK; KRAS; apoptosis; pancreatic cancer

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático Límite: Humans Idioma: En Revista: Cells Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Suiza

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