Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model.

Ni, Lu; Yamada, Takeshi; Murata, Asako; Nakatani, Kazuhiko

Ni, Lu; Yamada, Takeshi; Murata, Asako; Nakatani, Kazuhiko.

Afiliación

Ni L; SANKEN (The Institute of Scientific and Industrial Research), Osaka University, 8-1 Mihogaoka, Ibaraki 567-0047, Japan. nakatani@sanken.osaka-u.ac.jp.
Yamada T; SANKEN (The Institute of Scientific and Industrial Research), Osaka University, 8-1 Mihogaoka, Ibaraki 567-0047, Japan. nakatani@sanken.osaka-u.ac.jp.
Murata A; SANKEN (The Institute of Scientific and Industrial Research), Osaka University, 8-1 Mihogaoka, Ibaraki 567-0047, Japan. nakatani@sanken.osaka-u.ac.jp.
Nakatani K; SANKEN (The Institute of Scientific and Industrial Research), Osaka University, 8-1 Mihogaoka, Ibaraki 567-0047, Japan. nakatani@sanken.osaka-u.ac.jp.

Chem Commun (Camb) ; 58(22): 3629-3632, 2022 Mar 15.

Article en En | MEDLINE | ID: mdl-35201254

RESUMEN

Circular RNA (circRNA) is a covalently closed single-stranded RNA produced from pre-mRNAs via back-splicing reaction, an alternative form of splicing. Here, we show naphthyridine carbamate dimer (NCD) upregulating the production of a circRNA from a pre-mRNA containing NCD-binding site UGGAA/UGGAA in cells, demonstrating the feasibility of small-molecule mediated circRNA production.

Asunto(s)

Empalme del ARN; ARN Circular; Ligandos; ARN/genética; ARN/metabolismo; Precursores del ARN/genética

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Empalme del ARN / ARN Circular Idioma: En Revista: Chem Commun (Camb) Asunto de la revista: QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Reino Unido

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