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PGNMID and anti-CD38 monoclonal antibody: a therapeutic challenge.
Rahbari, Elnaz; Barreca, Antonella; Nicolino, Barbara; Ciochetto, Chiara; Piraina, Valentina; Maroni, Serena; Deagostini, Maria Chiara; Patti, Rosaria; Bertucci, Piergiorgio; Savoldi, Silvana.
Afiliación
  • Rahbari E; Nephrology and Dialysis Unit, ASL TO4, Turin, Italy.
  • Barreca A; Division of Pathology, Città della Salute e della Scienza Hospital, Turin, Italy.
  • Nicolino B; Hematology Unit ASL TO4, Turin, Italy.
  • Ciochetto C; Hematology Unit ASL TO4, Turin, Italy.
  • Piraina V; Nephrology and Dialysis Unit, ASL TO4, Turin, Italy.
  • Maroni S; Nephrology and Dialysis Unit, ASL TO4, Turin, Italy.
  • Deagostini MC; Nephrology and Dialysis Unit, ASL TO4, Turin, Italy.
  • Patti R; Nephrology and Dialysis Unit, ASL TO4, Turin, Italy.
  • Bertucci P; Public hygiene service ASL TO4, Turin, Italy.
  • Savoldi S; Nephrology and Dialysis Unit, ASL TO4, Turin, Italy.
G Ital Nefrol ; 39(1)2022 Feb 16.
Article en En | MEDLINE | ID: mdl-35191627
Monoclonal gammopathy of renal significance (MGRS) designates disorders induced by a monoclonal protein secreted by plasma cells or B-cell clones in patients who do not meet the diagnostic criteria for multiple myeloma or other B-cell malignancies. Proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID) is a form MGRS. Until now, no guidelines to decide the best therapeutic approach to manage PGNMID exist, and most patients progress to End Stage Renal Disease (ESRD) without therapy. Recently, daratumumab has showed an acceptable improvement in proteinuria and renal function in patients with PGNMID. We report the clinical outcome and the histological renal evolution and treatment complication of our patient, who was initially treated with a combination regimen including bortezomib, dexamethasone, and cyclophosphamide and then with anti-CD38 monoclonal antibody-based regimen.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glomerulonefritis Membranoproliferativa / Glomerulonefritis Tipo de estudio: Diagnostic_studies / Guideline Límite: Humans Idioma: En Revista: G Ital Nefrol Asunto de la revista: NEFROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia
Buscar en Google
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glomerulonefritis Membranoproliferativa / Glomerulonefritis Tipo de estudio: Diagnostic_studies / Guideline Límite: Humans Idioma: En Revista: G Ital Nefrol Asunto de la revista: NEFROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia